مرکز اطلاعات علمی Scientific Information Database (SID) - Trusted Source for Research and Academic Resources

video

مرکز اطلاعات علمی Scientific Information Database (SID) - Trusted Source for Research and Academic Resources

sound

مرکز اطلاعات علمی Scientific Information Database (SID) - Trusted Source for Research and Academic Resources

Persian Version

مرکز اطلاعات علمی Scientific Information Database (SID) - Trusted Source for Research and Academic Resources

View:

15
مرکز اطلاعات علمی Scientific Information Database (SID) - Trusted Source for Research and Academic Resources

Download:

4
مرکز اطلاعات علمی Scientific Information Database (SID) - Trusted Source for Research and Academic Resources

Cites:

Information Journal Paper

Title

Deregulation of apoptotic proteins by induction of Dendropthae falcata (L. f. ) Ettingsh plant extract in breast cancer cells: A proteome-wide analysis

Pages

  1202-1211

Abstract

 Objective(s): The present study evaluated the protein-based analysis to unravel the role and mechanism behind the Dendropthae falcata plant extract treatment in breast cancer cells. Materials and Methods: The protein sample was extracted from the cancer cells after treatment with the plant extract and subjected to two-dimensional electrophoresis for protein separation. Further, the proteins that were differentially regulated among the samples which were treated and non-treated were selected and processed further for protein identification using a tandem Mass spectrometry approach. Results: Using these strategies, we identified 16 potential candidates which were showing remarkable changes in treated samples. All the candidates were analyzed further for gene ontology analysis, and it was observed that all proteins were involved in multiple pathways pertaining to the carcinogenesis process. Specifically, apoptotic pathway proteins including BAD, BIK, BID, CASP8, MCL1, BCL2, and BAK1 were highly impacted by treatment with D. falcata plant extract. All these protein hits were further taken for validation experiments using RT PCR analysis. Conclusion: Initiation of these apoptotic proteins by D. falcata plant extract treatment in breast cancer cells shows a positive direction toward nature-based alternative medicine.

Cites

  • No record.

    • References

    Cite

    APA: Copy

    Durairaj, Alwin Beschi, Monikam, Reginald Appavoo, Krishnamoorthy, Rajapandiyan, Ahmed, Mohammad Z., Alqahtani, Ali S., & Mydeen, Ponnani Kaja. (2023). Deregulation of apoptotic proteins by induction of Dendropthae falcata (L. f. ) Ettingsh plant extract in breast cancer cells: A proteome-wide analysis. IRANIAN JOURNAL OF BASIC MEDICAL SCIENCES, 26(10), 1202-1211. SID. https://sid.ir/paper/1084891/en

    Vancouver: Copy

    Durairaj Alwin Beschi, Monikam Reginald Appavoo, Krishnamoorthy Rajapandiyan, Ahmed Mohammad Z., Alqahtani Ali S., Mydeen Ponnani Kaja. Deregulation of apoptotic proteins by induction of Dendropthae falcata (L. f. ) Ettingsh plant extract in breast cancer cells: A proteome-wide analysis. IRANIAN JOURNAL OF BASIC MEDICAL SCIENCES[Internet]. 2023;26(10):1202-1211. Available from: https://sid.ir/paper/1084891/en

    IEEE: Copy

    Alwin Beschi Durairaj, Reginald Appavoo Monikam, Rajapandiyan Krishnamoorthy, Mohammad Z. Ahmed, Ali S. Alqahtani, and Ponnani Kaja Mydeen, “Deregulation of apoptotic proteins by induction of Dendropthae falcata (L. f. ) Ettingsh plant extract in breast cancer cells: A proteome-wide analysis,” IRANIAN JOURNAL OF BASIC MEDICAL SCIENCES, vol. 26, no. 10, pp. 1202–1211, 2023, [Online]. Available: https://sid.ir/paper/1084891/en

    Related Journal Papers

  • No record.

    • Related Seminar Papers

  • No record.

    • Related Plans

  • No record.

    • Recommended Workshops






    Move to top
    telegram sharing button
    whatsapp sharing button
    linkedin sharing button
    twitter sharing button
    email sharing button
    email sharing button
    email sharing button
    sharethis sharing button