Acetyl-L-carnitine for the prevention of taxane-induced neuropathy in patients with breast cancer: a systematic review and meta-analysis

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Momenzadeh Mahnaz; Aria Amir; GHADIMI KEYVAN; MOGHADDAS AZADEH

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Journal Paper

Paper Information

Journal: RESEARCH IN PHARMACEUTICAL SCIENCES (RPS) Year:2023 | Volume:18 | Issue:2 Page(s): 112-120

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Title

Acetyl-L-carnitine for the prevention of taxane-induced neuropathy in patients with breast cancer: a systematic review and meta-analysis

Author(s)

Momenzadeh Mahnaz | Aria Amir | GHADIMI KEYVAN | MOGHADDAS AZADEH | Issue Writer Certificate

Keywords

Acetyl-L-carnitine

Breast cancer

Chemotherapy

Neuropathy

Taxane

Abstract

Background and purpose: Peripheral Neuropathy is one of the most prevalent and undesirable side effects of Taxane-containing Chemotherapy regimens. This study aimed to investigate the effect of Acetyl-L-carnitine (ALC) on the prevention of Taxane-induced Neuropathy (TIN). Experimental approach: MEDLINE, PubMed, Cochrane Library, Embase, Web of Science, and Google scholar were systemically applied as electronic databases from 2010 to 2019. The current systematic review was carried out based on the main considerations of PRISMA preferential reporting items for systematic review and meta-analyses. Since there was no significant discrepancy, the random-effect model was used for 12-24 weeks’,analysis (I2 = 0%, P = 0. 999). Findings/Results: Twelve related titles and abstracts were found during the search, 6 of them were excluded in the first phase. In the second phase, the full text of the remaining 6 articles was comprehensively evaluated and 3 papers were rejected. Finally, 3 articles complied with the inclusion criteria and pooled analyses. The meta-analysis showed a risk ratio of 0. 796 (95% CI between 0. 486 and 1. 303), so, the effects model was used for 12-24 weeks’,analysis (I2 = 0%, P = 0. 999) since no significant discrepancies were observed. There was no evidence of ALC’, s positive effect on the prevention of TIN during 12 weeks, and it was revealed that ALC significantly increased TIN in 24 weeks. Conclusion and implications: According to our findings, the hypothesis that ALC had a positive effect on preventing TIN in 12 weeks has not been proved,however, ALC led to an increase in the TIN in 24 weeks.

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APA: Copy

Momenzadeh, Mahnaz, Aria, Amir, GHADIMI, KEYVAN, & MOGHADDAS, AZADEH. (2023). Acetyl-L-carnitine for the prevention of taxane-induced neuropathy in patients with breast cancer: a systematic review and meta-analysis. RESEARCH IN PHARMACEUTICAL SCIENCES (RPS), 18(2), 112-120. SID. https://sid.ir/paper/1085242/en

Vancouver: Copy

Momenzadeh Mahnaz, Aria Amir, GHADIMI KEYVAN, MOGHADDAS AZADEH. Acetyl-L-carnitine for the prevention of taxane-induced neuropathy in patients with breast cancer: a systematic review and meta-analysis. RESEARCH IN PHARMACEUTICAL SCIENCES (RPS)[Internet]. 2023;18(2):112-120. Available from: https://sid.ir/paper/1085242/en

IEEE: Copy

Mahnaz Momenzadeh, Amir Aria, KEYVAN GHADIMI, and AZADEH MOGHADDAS, “Acetyl-L-carnitine for the prevention of taxane-induced neuropathy in patients with breast cancer: a systematic review and meta-analysis,” RESEARCH IN PHARMACEUTICAL SCIENCES (RPS), vol. 18, no. 2, pp. 112–120, 2023, [Online]. Available: https://sid.ir/paper/1085242/en

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