Antihypertensive, antidyslipidemic, and renoprotective effects of Bursera simaruba on metabolic syndrome

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Guzman Hernandez Elizabeth Alejandrina; Segura Cobos David; Gonzalez Valle Maria del Rosario; Benitez Flores Jose del Carmen; Miguel Chavez Ruben San; Valle Mondragon Leonardo del; Magos Guerrero Gil Alfonso; Lopez Sanchez Pedro

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Journal Paper

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Journal: Iranian Journal of Basic Medical Sciences Year:2023 | Volume:26 | Issue:4 Page(s): 414-419

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Title

Antihypertensive, antidyslipidemic, and renoprotective effects of Bursera simaruba on metabolic syndrome

Author(s)

Keywords

Blood pressure

Bursera simaruba

Hyperlipidemia

Kidney failure

Metabolic syndrome

Obesity

Oxidative stress

Abstract

Objective(s): Metabolic syndrome is associated with the development of chronic kidney disease. Bursera simaruba “, chaca”,is a medicinal plant used in Mexico for hypertension and empirical therapy. In this study, were examined the effects of ethanol extract of B. simaruba on Metabolic syndrome. Materials and Methods: For induction of Metabolic syndrome, 20% fructose was used, and it was administered in the water and food to male Wistar rats for 12 weeks, after administering ethanol extract of B. simaruba intragastrically (100 and 200 mg/kg/day) for 6 weeks, Blood pressure was determined. In plasma, glucose, cholesterol, triglycerides, angiotensin II, oxide nitric, and angiotensin 1-7 were quantified. In the kidney was performed histological study and the activity of anti-oxidant enzymes was quantified. Results: Rats with Metabolic syndrome developed Obesity, arterial hypertension, dyslipidemia, and kidney damage characterized by proliferative glomerulonephritis, necrosis, and reduced activity of anti-oxidant enzymes. These alterations were significantly ameliorated by ethanol extract of B. simaruba. Conclusion: The ethanolic extract of B. simaruba showed antidyslipidemic, antihypertensive, anti-oxidant, and renoprotective effects.

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APA: Copy

Guzman Hernandez, Elizabeth Alejandrina, Segura Cobos, David, Gonzalez Valle, Maria del Rosario, Benitez Flores, Jose del Carmen, Miguel Chavez, Ruben San, Valle Mondragon, Leonardo del, Magos Guerrero, Gil Alfonso, & Lopez Sanchez, Pedro. (2023). Antihypertensive, antidyslipidemic, and renoprotective effects of Bursera simaruba on metabolic syndrome. IRANIAN JOURNAL OF BASIC MEDICAL SCIENCES, 26(4), 414-419. SID. https://sid.ir/paper/1085275/en

Vancouver: Copy

Guzman Hernandez Elizabeth Alejandrina, Segura Cobos David, Gonzalez Valle Maria del Rosario, Benitez Flores Jose del Carmen, Miguel Chavez Ruben San, Valle Mondragon Leonardo del, Magos Guerrero Gil Alfonso, Lopez Sanchez Pedro. Antihypertensive, antidyslipidemic, and renoprotective effects of Bursera simaruba on metabolic syndrome. IRANIAN JOURNAL OF BASIC MEDICAL SCIENCES[Internet]. 2023;26(4):414-419. Available from: https://sid.ir/paper/1085275/en

IEEE: Copy

Elizabeth Alejandrina Guzman Hernandez, David Segura Cobos, Maria del Rosario Gonzalez Valle, Jose del Carmen Benitez Flores, Ruben San Miguel Chavez, Leonardo del Valle Mondragon, Gil Alfonso Magos Guerrero, and Pedro Lopez Sanchez, “Antihypertensive, antidyslipidemic, and renoprotective effects of Bursera simaruba on metabolic syndrome,” IRANIAN JOURNAL OF BASIC MEDICAL SCIENCES, vol. 26, no. 4, pp. 414–419, 2023, [Online]. Available: https://sid.ir/paper/1085275/en

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