مرکز اطلاعات علمی Scientific Information Database (SID) - Trusted Source for Research and Academic Resources

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Information Journal Paper

Title

The electrical stimulation of the central nucleus of the amygdala in combination with dopamine receptor antagonist reduces the acquisition phase of morphine-induced conditioned place preference in male rat

Pages

  430-438

Abstract

 Background and purpose: The central nucleus of the amygdala (CeA) is one of the nuclei involved in the reward system. The aim of the current study was to investigate the electrical stimulation (e-stim) effect of the CeA in combination with dopamine D1 receptor antagonist on morphine-induced conditioned place preference (CPP) in male Rats. Experimental approach: A 5-day procedure of CPP was used in this study. Morphine was administered at an effective dose of 5 mg/kg, and SCH23390 as a selective D1 receptor antagonist was administrated into the CeA. In addition, the CeA was stimulated with an intensity of the current of 150 μ, A. Finally, the dependence on morphine was evaluated in all experimental groups. Findings /Results: Morphine significantly increased CPP. While the blockade of the D1 receptor of the CeA reduced the acquisition phase of morphine-induced CPP. Moreover, the combination of D1 receptor antagonist and e-stim suppressed morphine-induced CPP, even it induced an aversion. Conclusion and implication: The current study suggests that the administration of dopamine D1 receptor antagonist into the CeA in combination with e-stim could play a prominent role in Morphine dependence.

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    Cite

    APA: Copy

    JOKAR, ZAHRA, KHATAMSAZ, SAEED, ALAEI, HOJJATALLAH, & SHARIATI, MEHRDAD. (2023). The electrical stimulation of the central nucleus of the amygdala in combination with dopamine receptor antagonist reduces the acquisition phase of morphine-induced conditioned place preference in male rat. RESEARCH IN PHARMACEUTICAL SCIENCES (RPS), 18(4), 430-438. SID. https://sid.ir/paper/1085349/en

    Vancouver: Copy

    JOKAR ZAHRA, KHATAMSAZ SAEED, ALAEI HOJJATALLAH, SHARIATI MEHRDAD. The electrical stimulation of the central nucleus of the amygdala in combination with dopamine receptor antagonist reduces the acquisition phase of morphine-induced conditioned place preference in male rat. RESEARCH IN PHARMACEUTICAL SCIENCES (RPS)[Internet]. 2023;18(4):430-438. Available from: https://sid.ir/paper/1085349/en

    IEEE: Copy

    ZAHRA JOKAR, SAEED KHATAMSAZ, HOJJATALLAH ALAEI, and MEHRDAD SHARIATI, “The electrical stimulation of the central nucleus of the amygdala in combination with dopamine receptor antagonist reduces the acquisition phase of morphine-induced conditioned place preference in male rat,” RESEARCH IN PHARMACEUTICAL SCIENCES (RPS), vol. 18, no. 4, pp. 430–438, 2023, [Online]. Available: https://sid.ir/paper/1085349/en

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