Effect of 4 Weeks Preconditioning with High Intensity Interval Training and Moderate Intensity Continuous Training on Brain Levels of TNF-Α,and TLR4 in Male Wistar Rats

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Foroughi Pordanjani Abbas; SALESI MOHSEN; REZAEI RASOUL; NEMATI JAVAD

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Journal Paper

Paper Information

Journal: Journal of Shahid Sadoughi University of Medical Sciences Year:2023 | Volume:30 | Issue:10 Page(s): 6000-6012

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Title

Effect of 4 Weeks Preconditioning with High Intensity Interval Training and Moderate Intensity Continuous Training on Brain Levels of TNF-Α,and TLR4 in Male Wistar Rats

Author(s)

Foroughi Pordanjani Abbas | SALESI MOHSEN | REZAEI RASOUL | NEMATI JAVAD | Issue Writer Certificate

Keywords

HIIT

MICT

Preconditioning

TNF-α

TLR4

Abstract

Introduction: Inflammation in the brain is known as neuroinflammation and increases TNF-α,(Tumor necrosis factor alpha) secretion and activates the TLR4 (Toll-like receptor 4) pathway. The aim of this study was to evaluate the effect of 4 weeks Preconditioning with high intensity intermittent training (HIIT) and moderate intensity training (MICT) on TNF-α,and TLR4 levels in male Wistar rats. Methods: The current research was an experimental study. 18 male Wistar rats were divided into three groups: high intensity intermittent training (6 heads), continuous moderate intensity training (6 heads) and the control group (6 heads). HIIT program included 6 stages of 2-minute activity with intensity of 85-90% VO2max and 5 stages of active rest for 2 minutes and MICT program with intensity of 65% VO2max with the same duration as HIIT for 4 weeks and 5 days per week was implemented. 48 hours after the last training session, rats were dissected and cortical tissues and layers of mice were extracted for TNF-α,and TLR-4 using western blotting. Data analysis was performed using ANOVA test at a significance level of 0. 05 With the help of SPSS version 16 software. Results: The results of the present study showed that TNF-α,and TLR4 in the cortex and stratum cerebral areas after 4 weeks of high-intensity and moderate-intensity intermittent aerobic exercise did not change significantly compared to the control group (p≥, 0. 05). Conclusion: According to these findings, it can be stated that exercise with high or moderate intensity cannot be an effective factor in increasing inflammatory markers in the brain.

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APA: Copy

Foroughi Pordanjani, Abbas, SALESI, MOHSEN, REZAEI, RASOUL, & NEMATI, JAVAD. (2023). Effect of 4 Weeks Preconditioning with High Intensity Interval Training and Moderate Intensity Continuous Training on Brain Levels of TNF-Α,and TLR4 in Male Wistar Rats. JOURNAL OF SHAHID SADOUGHI UNIVERSITY OF MEDICAL SCIENCES, 30(10 ), 6000-6012. SID. https://sid.ir/paper/1087806/en

Vancouver: Copy

Foroughi Pordanjani Abbas, SALESI MOHSEN, REZAEI RASOUL, NEMATI JAVAD. Effect of 4 Weeks Preconditioning with High Intensity Interval Training and Moderate Intensity Continuous Training on Brain Levels of TNF-Α,and TLR4 in Male Wistar Rats. JOURNAL OF SHAHID SADOUGHI UNIVERSITY OF MEDICAL SCIENCES[Internet]. 2023;30(10 ):6000-6012. Available from: https://sid.ir/paper/1087806/en

IEEE: Copy

Abbas Foroughi Pordanjani, MOHSEN SALESI, RASOUL REZAEI, and JAVAD NEMATI, “Effect of 4 Weeks Preconditioning with High Intensity Interval Training and Moderate Intensity Continuous Training on Brain Levels of TNF-Α,and TLR4 in Male Wistar Rats,” JOURNAL OF SHAHID SADOUGHI UNIVERSITY OF MEDICAL SCIENCES, vol. 30, no. 10 , pp. 6000–6012, 2023, [Online]. Available: https://sid.ir/paper/1087806/en

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