The sequence variation of mitochondrial tRNA tyrosine and cysteine among Iranian women with idiopathic recurrent miscarriage: A case-control study

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Mojodi Elham; Mosadegh Mehrjardi Alimohammad; Naeimzadeh Yasaman; Ghasemi Nasrin; Falahati ALI; Moshtaghioun Seyed Mohammad

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Journal: International Journal of Reproductive BioMedicine Year:621 | Volume: | Issue: Page(s): 567-576

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Title

The sequence variation of mitochondrial tRNA tyrosine and cysteine among Iranian women with idiopathic recurrent miscarriage: A case-control study

Author(s)

Keywords

Recurrent early pregnancy lossQ4

mtDNAQ4

SNPsQ4

Heteroplasmy.Q4

Abstract

Background: Recurrent miscarriage is one of the most prevalent reproductive diseases. This phenomenon has several reasons, including maternal, hormonal, immunological, and parental genetic factors. Idiopathic recurrent miscarriage (IRM), with no distinctive etiology, involves about half of the recurrent miscarriage cases. Some mutations in mitochondrial DNA can lead to miscarriage. Mitochondrial tRNA (mt-tRNA) mutations cause nearly half of the mitochondrial disorders. Objective: To identify mt- tRNACys & Tyr gene mutations in Iranian women with IRM. Materials and Methods: In this case-control study, 100 Iranian women with IRM and 100 women as control without any history of miscarriage were investigated by polymerase chain reaction-single strand conformation polymorphism technique followed by gene sequencing. Bioinformatics analysis were done using human mitochondrial genome database, molecular evolutionary genetics analysis, mammalian mitochondrial-tRNA, etc. Results: Results showed 4 mt-tRNA mutations including 1 cysteine mt-tRNA mutation (5824C>T) and 3 tyrosine mt-tRNA mutations (5868T>A, 5849C>T, and 5836T>C) in our cases. Conclusion: Amongst the 4 mutations found, one was novel that is still not reported. Our bioinformatics analysis revealed that these mutations can be pathogenic. They occurred in tRNA-conserved regions and their secondary structure was changed, which can result in mitochondrial dysfunction. Mutations of these genes may help in the assessment of IRM. Further study of all 22 mt-tRNAs possible mutations is recommended to describe their etiologic role in IRM.

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APA: Copy

Mojodi, Elham, Mosadegh Mehrjardi, Alimohammad, Naeimzadeh, Yasaman, GHASEMI, NASRIN, FALAHATI, ALI, & MOSHTAGHIOUN, SEYED MOHAMMAD. (2023). The sequence variation of mitochondrial tRNA tyrosine and cysteine among Iranian women with idiopathic recurrent miscarriage: A casecontrol study. INTERNATIONAL JOURNAL OF REPRODUCTIVE BIOMEDICINE (IRANIAN JOURNAL OF REPRODUCTIVE MEDICINE), 21(7), 567-576. SID. https://sid.ir/paper/1088775/en

Vancouver: Copy

Mojodi Elham, Mosadegh Mehrjardi Alimohammad, Naeimzadeh Yasaman, GHASEMI NASRIN, FALAHATI ALI, MOSHTAGHIOUN SEYED MOHAMMAD. The sequence variation of mitochondrial tRNA tyrosine and cysteine among Iranian women with idiopathic recurrent miscarriage: A casecontrol study. INTERNATIONAL JOURNAL OF REPRODUCTIVE BIOMEDICINE (IRANIAN JOURNAL OF REPRODUCTIVE MEDICINE)[Internet]. 2023;21(7):567-576. Available from: https://sid.ir/paper/1088775/en

IEEE: Copy

Elham Mojodi, Alimohammad Mosadegh Mehrjardi, Yasaman Naeimzadeh, NASRIN GHASEMI, ALI FALAHATI, and SEYED MOHAMMAD MOSHTAGHIOUN, “The sequence variation of mitochondrial tRNA tyrosine and cysteine among Iranian women with idiopathic recurrent miscarriage: A casecontrol study,” INTERNATIONAL JOURNAL OF REPRODUCTIVE BIOMEDICINE (IRANIAN JOURNAL OF REPRODUCTIVE MEDICINE), vol. 21, no. 7, pp. 567–576, 2023, [Online]. Available: https://sid.ir/paper/1088775/en

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