The time course of nod-like receptor family pyrin domain containing 3 inflammasome complex expressions in the testis tissue of an experimental varicocele rat model: An experimental study

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Fallah Asl Hamideh; Jalali Mashayekhi Farideh; Zendedel Adib; Baazm Maryam

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Journal Paper

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Journal: International Journal of Reproductive BioMedicine Year:621 | Volume: | Issue: Page(s): 577-584

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Title

The time course of nod-like receptor family pyrin domain containing 3 inflammasome complex expressions in the testis tissue of an experimental varicocele rat model: An experimental study

Author(s)

Fallah Asl Hamideh | Jalali Mashayekhi Farideh | Zendedel Adib | Baazm Maryam | Issue Writer Certificate

Keywords

VaricoceleQ4

InflammasomesQ4

NLRP3Q4

Rat.Q4

Abstract

Background: Varicocele is characterized by abnormal dilation of the testicular vein, which results in hypoxia, the accumulation of reactive oxygen species, and the production of proinflammatory cytokines. It seems that a group of cytosolic receptors named nod-like receptor family, pyrin domain containing 3 (NLRP3) inflammasome, is activated and involved in the pathogenesis of Varicocele. Objective: We aim to determine the time course of NLRP3 inflammasome expression in the testis tissue following Varicocele induction. Materials and Methods: In this experimental study, 36 adult Wistar Rat. (8 wk, 200-250 gr) were used. For the Varicocele induction, the left renal vein was partially ligated. The mRNA levels of NLRP3, apoptosis-associated speck-like protein containing a caspase recruitment domain, and caspase-1 were evaluated by real-time polymerase chain reaction at 1, 2, 4, 8, and 12 wk after Varicocele induction. Results: Results showed that the gene expression of NLRP3 inflammasome component including NLRP3, apoptosis-associated speck-like protein containing a caspase recruitment domain, and caspase-1 did not alter during week 1, 2, 4, and 8 after opeRat.on (p = 0.09). 12 wk after Varicocele induction, gene expression levels were significantly up-regulated (p = 0.02). Conclusion: Our data provides clear evidence that Varicocele stimulates inflammasome activation in the testis tissue 12 wk after the opeRat.on, and this time is required for investigating NLRP3 activity in the Varicocele Rat.model.

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APA: Copy

Fallah Asl, Hamideh, JALALI MASHAYEKHI, FARIDEH, ZENDEDEL, ADIB, & BAAZM, MARYAM. (2023). The time course of nod-like receptor family pyrin domain containing 3 inflammasome complex expressions in the testis tissue of an experimental varicocele rat model: An experimental study. INTERNATIONAL JOURNAL OF REPRODUCTIVE BIOMEDICINE (IRANIAN JOURNAL OF REPRODUCTIVE MEDICINE), 21(7), 577-584. SID. https://sid.ir/paper/1088779/en

Vancouver: Copy

Fallah Asl Hamideh, JALALI MASHAYEKHI FARIDEH, ZENDEDEL ADIB, BAAZM MARYAM. The time course of nod-like receptor family pyrin domain containing 3 inflammasome complex expressions in the testis tissue of an experimental varicocele rat model: An experimental study. INTERNATIONAL JOURNAL OF REPRODUCTIVE BIOMEDICINE (IRANIAN JOURNAL OF REPRODUCTIVE MEDICINE)[Internet]. 2023;21(7):577-584. Available from: https://sid.ir/paper/1088779/en

IEEE: Copy

Hamideh Fallah Asl, FARIDEH JALALI MASHAYEKHI, ADIB ZENDEDEL, and MARYAM BAAZM, “The time course of nod-like receptor family pyrin domain containing 3 inflammasome complex expressions in the testis tissue of an experimental varicocele rat model: An experimental study,” INTERNATIONAL JOURNAL OF REPRODUCTIVE BIOMEDICINE (IRANIAN JOURNAL OF REPRODUCTIVE MEDICINE), vol. 21, no. 7, pp. 577–584, 2023, [Online]. Available: https://sid.ir/paper/1088779/en

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