Liver X Receptor as a Possible Drug Target for Blood-Brain Barrier Integrity

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ESKANDARI MAHSA; Awsat Mellati Ali

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Journal Paper

Paper Information

Journal: Advanced Pharmaceutical Bulletin Year:2022 | Volume:12 | Issue:3 Page(s): 466-475

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Information Journal Paper

Title

Liver X Receptor as a Possible Drug Target for Blood-Brain Barrier Integrity

Author(s)

ESKANDARI MAHSA | Awsat Mellati Ali | Issue Writer Certificate

Keywords

Blood-brain barrier

Liver X receptor

Drug delivery

LXR

BBB

Abstract

Purpose: Blood-brain barrier (BBB) is made of specialized cells that are responsible for the selective passage of substances directed to the brain. The integrated BBB is essential for precise controlling of the different substances passage as well as protecting the brain from various damages. In this article, we attempted to explain the role of Liver X receptor (LXR) in maintaining BBB integrity as a possible drug target. Methods: In this study, various databases, including PubMed, Google Scholar, and Scopus were searched using the following keywords: Blood-brain barrier, BBB, Liver X receptor, and LXR until July, 2020. Additionally, contents close to the subject of our study were surveyed. Results: LXR is a receptor the roles of which in various diseases have been investigated. LXR can affect maintaining BBB by affecting various ways such as ATP-binding cassette transporter A1 (ABCA1), matrix metalloproteinase-9 (MMP9), insulin-like growth factor 1 (IGF1), nuclear factor-kappa B (NF-κ, B) signaling, mitogen-activated protein kinase (MAPK), tight junction molecules, both signal transducer and activator of transcription 1 (STAT1), Wnt/β,-catenin Signaling, transforming growth factor beta (TGF-β, ) signaling, and expressions of Smad 2/3 and Snail. Conclusion: LXR could possibly be used either as a target for Drug delivery to brain tissue or as a target for maintaining the BBB integrity in different diseases,thereby the drug will be conducted to tissues, other than the brain. If it is verified that only LXRα,is necessary for protecting BBB, some specific LXRα,ligands must be found and then used in medication.

Cites

24-Hydroxycholesterol Moderates the Effects of Amyloid-β on Expression of HMG-CoA Reductase and ABCA1 Proteins in Mouse Astrocytes

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APA: Copy

ESKANDARI, MAHSA, & Awsat Mellati, Ali. (2022). Liver X Receptor as a Possible Drug Target for Blood-Brain Barrier Integrity. ADVANCED PHARMACEUTICAL BULLETIN, 12(3), 466-475. SID. https://sid.ir/paper/1089147/en

Vancouver: Copy

ESKANDARI MAHSA, Awsat Mellati Ali. Liver X Receptor as a Possible Drug Target for Blood-Brain Barrier Integrity. ADVANCED PHARMACEUTICAL BULLETIN[Internet]. 2022;12(3):466-475. Available from: https://sid.ir/paper/1089147/en

IEEE: Copy

MAHSA ESKANDARI, and Ali Awsat Mellati, “Liver X Receptor as a Possible Drug Target for Blood-Brain Barrier Integrity,” ADVANCED PHARMACEUTICAL BULLETIN, vol. 12, no. 3, pp. 466–475, 2022, [Online]. Available: https://sid.ir/paper/1089147/en

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