Evaluation of AURKA rs2273535 and CDKN1B rs34330 Polymorphisms Association with the Risk of Breast Cancer

Q: How can I download an article?

To download an article from SID, first log in to the site, search for the article title, and click on the 'Download Article' option.

Q: How can I download an ISI article?

To download an ISI article on SID, enter the keyword or article title in the search bar, view the relevant results, click on the desired article, and select the 'Download Article' option.

Q: How can I access the SID database?

To access the SID database, visit SID.ir, create an account, and log in to access scientific resources.

Q: Is downloading articles from SID free?

Some articles on SID are available for free, while others require payment. Details are specified on the article's page.

Liravi Atefeh; Houshmand Seyed Massoud; JAFARNIA MOJTABA; FOROUZANFAR MOHSEN

مرکز اطلاعات علمی Scientific Information Database (SID) - Trusted Source for Research and Academic Resources

Journal Paper

Paper Information

Journal: Journal of Advanced Biomedical Sciences Year:2022 | Volume:12 | Issue:4 Page(s): 422-430

Download Full-Text

View:

Download:

Cites:

Information Journal Paper

Title

Evaluation of AURKA rs2273535 and CDKN1B rs34330 Polymorphisms Association with the Risk of Breast Cancer

Author(s)

Liravi Atefeh | Houshmand Seyed Massoud | JAFARNIA MOJTABA | FOROUZANFAR MOHSEN | Issue Writer Certificate

Keywords

Breast cancer

AURKA

CDKN1B

rs2273535

rs34330

RFLP

Abstract

Background & Objective: Breast cancer consists of a heterogeneous group of tumours with different prognosis and is the most common cause of cancer-related mortality among women. In this study, our goal was to evaluate the association of AURKA rs2273535 and CDKN1B rs34330 polymorphisms with risk of female Breast cancer in southwest part of Iran. Materials & Methods: This case-control study was done on 50 women with Breast cancer and 50 healthy women without any symptoms or family history of Breast cancer as the case and control group, respectively. Restriction fragment length polymorphism (RFLP-PCR) technique was designed to determine the AURKA rs2273535 and CDKN1B rs34330 gene polymorphisms. Afterwards, statistical analysis was done by means of SPSS (version 17). Results: In current research, our finding showed that rs2273535 T allele increased the susceptibility of Breast cancer (OR: 2. 58, 95%CI: 1. 5-31. 09, P=0. 006). Moreover, T allele in dominant phase could raise the risk of the Breast cancer (OR: 3. 01, 65%CI: 1. 31-6. 92, P=0. 009). However, the other polymorphism, CDKN1B rs34330, revealed no associations with increased risk of Breast cancer. Conclusion: These findings suggest that AURKA rs2273535 may influence individual’, s susceptibility to Breast cancer. But we found no associations regarding CDKN1B rs34330 polymorphism and this type of cancer.

Cites

No record.

References

No record.

Cite

APA: Copy

Liravi, Atefeh, Houshmand, Seyed Massoud, JAFARNIA, MOJTABA, & FOROUZANFAR, MOHSEN. (2022). Evaluation of AURKA rs2273535 and CDKN1B rs34330 Polymorphisms Association with the Risk of Breast Cancer. JOURNAL OF ADVANCED BIOMEDICAL SCIENCES, 12(4), 422-430. SID. https://sid.ir/paper/1089867/en

Vancouver: Copy

Liravi Atefeh, Houshmand Seyed Massoud, JAFARNIA MOJTABA, FOROUZANFAR MOHSEN. Evaluation of AURKA rs2273535 and CDKN1B rs34330 Polymorphisms Association with the Risk of Breast Cancer. JOURNAL OF ADVANCED BIOMEDICAL SCIENCES[Internet]. 2022;12(4):422-430. Available from: https://sid.ir/paper/1089867/en

IEEE: Copy

Atefeh Liravi, Seyed Massoud Houshmand, MOJTABA JAFARNIA, and MOHSEN FOROUZANFAR, “Evaluation of AURKA rs2273535 and CDKN1B rs34330 Polymorphisms Association with the Risk of Breast Cancer,” JOURNAL OF ADVANCED BIOMEDICAL SCIENCES, vol. 12, no. 4, pp. 422–430, 2022, [Online]. Available: https://sid.ir/paper/1089867/en

Related Journal Papers

No record.

Related Seminar Papers

No record.

Related Plans

No record.

Recommended Workshops