Electrosprayed Nanoparticles Containing Hydroalcoholic Extract of Echinacea purpurea (L. ) Moench Stimulates Immune System by Increasing Inflammatory Factors in Male Wistar Rats

Q: How can I download an article?

To download an article from SID, first log in to the site, search for the article title, and click on the 'Download Article' option.

Q: How can I download an ISI article?

To download an ISI article on SID, enter the keyword or article title in the search bar, view the relevant results, click on the desired article, and select the 'Download Article' option.

Q: How can I access the SID database?

To access the SID database, visit SID.ir, create an account, and log in to access scientific resources.

Q: Is downloading articles from SID free?

Some articles on SID are available for free, while others require payment. Details are specified on the article's page.

MEHDIZADEH FATEMEH; MOHAMMADZADEH RAMIN; NAZEMIYEH HOSSEIN; MESGARI ABBASI MEHRAN; BARZEGAR JALALI MOHAMMAD; Eskandani Morteza; ADIBKIA KHOSRO

مرکز اطلاعات علمی Scientific Information Database (SID) - Trusted Source for Research and Academic Resources

Journal Paper

Paper Information

Journal: Advanced Pharmaceutical Bulletin Year:2023 | Volume:13 | Issue:2 Page(s): 283-289

Download Full-Text

View:

Download:

Cites:

Information Journal Paper

Title

Electrosprayed Nanoparticles Containing Hydroalcoholic Extract of Echinacea purpurea (L. ) Moench Stimulates Immune System by Increasing Inflammatory Factors in Male Wistar Rats

Author(s)

Keywords

Electrospray

Echinacea purpurea

Eudragit RS100

Nanoparticles

Immune system

Abstract

Purpose: Echinacea purpurea (L. ) Moench is a member of the Asteraceae family and is traditionally used mainly due to its immunostimulatory properties. Various compounds including alkylamides and chicoric acid were reported as active ingredients of E. purpurea. Here, we aimed to prepare Electrosprayed Nanoparticles (NPs) containing hydroalcoholic extract of E. purpurea using Eudragit RS100 (EP-Eudragit RS100 NPs) to improve the immunomodulatory effects of the extract. Methods: The EP-Eudragit RS100 NPs with the different extract: polymer ratios and solution concentrations were prepared using the Electrospray technique. The size and morphology of the NPs were evaluated using dynamic light scattering (DLS) and field emission-scanning electron microscopy (FE-SEM). To evaluate the immune responses, male Wistar rats were administrated with the prepared EP-Eudragit RS100 NPs and plain extract in the final dose of 30 or 100 mg/kg. The blood samples of the animals were collected and the inflammatory factors and complete blood count (CBC) were investigated. Results: In vivo studies indicated that the plain extract and EP-Eudragit RS100 NPs (100 mg/kg) significantly increased the serum level of tumor necrosis factor-α,(TNF-α, ) and interleukin 1-β,(IL1-β, ) whereas the EP-Eudragit RS100 NPs (30 mg/kg) significantly increased the number of white blood cells (WBCs) compared to the control group. Lymphocytes’,count in all groups was increased significantly compared to the control group (P < 0. 05) whereas other CBC parameters remained unchanged. Conclusion: The prepared EP-Eudragit RS100 NPs by Electrospray technique caused significant reinforcement in the immunostimulatory effects of the extract of E. purpurea.

Cites

No record.

References

No record.

Cite

APA: Copy

MEHDIZADEH, FATEMEH, MOHAMMADZADEH, RAMIN, NAZEMIYEH, HOSSEIN, MESGARI ABBASI, MEHRAN, BARZEGAR JALALI, MOHAMMAD, Eskandani, Morteza, & ADIBKIA, KHOSRO. (2023). Electrosprayed Nanoparticles Containing Hydroalcoholic Extract of Echinacea purpurea (L. ) Moench Stimulates Immune System by Increasing Inflammatory Factors in Male Wistar Rats. ADVANCED PHARMACEUTICAL BULLETIN, 13(2), 283-289. SID. https://sid.ir/paper/1090158/en

Vancouver: Copy

MEHDIZADEH FATEMEH, MOHAMMADZADEH RAMIN, NAZEMIYEH HOSSEIN, MESGARI ABBASI MEHRAN, BARZEGAR JALALI MOHAMMAD, Eskandani Morteza, ADIBKIA KHOSRO. Electrosprayed Nanoparticles Containing Hydroalcoholic Extract of Echinacea purpurea (L. ) Moench Stimulates Immune System by Increasing Inflammatory Factors in Male Wistar Rats. ADVANCED PHARMACEUTICAL BULLETIN[Internet]. 2023;13(2):283-289. Available from: https://sid.ir/paper/1090158/en

IEEE: Copy

FATEMEH MEHDIZADEH, RAMIN MOHAMMADZADEH, HOSSEIN NAZEMIYEH, MEHRAN MESGARI ABBASI, MOHAMMAD BARZEGAR JALALI, Morteza Eskandani, and KHOSRO ADIBKIA, “Electrosprayed Nanoparticles Containing Hydroalcoholic Extract of Echinacea purpurea (L. ) Moench Stimulates Immune System by Increasing Inflammatory Factors in Male Wistar Rats,” ADVANCED PHARMACEUTICAL BULLETIN, vol. 13, no. 2, pp. 283–289, 2023, [Online]. Available: https://sid.ir/paper/1090158/en

Related Journal Papers

No record.

Related Seminar Papers

No record.

Related Plans

No record.

Recommended Workshops