مرکز اطلاعات علمی Scientific Information Database (SID) - Trusted Source for Research and Academic Resources

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Information Journal Paper

Title

Expression of MicroRNA-155 in Patients with Non-Hodgkin Lymphoma, Coronavirus Disease 2019, or Both: A Cross-Sectional Study

Pages

  26-34

Abstract

 Background: Non-Hodgkin Lymphoma (NHL) is the eleventh leading cause of cancer-related death in the world. Diffuse large B-cell Lymphoma (DLBCL) is the most common type of NHL. Up to winter 2021-2022, the death toll caused by the coronavirus disease 2019 (COVID-19) has exceeded 5. 6 million worldwide. Possible molecular mechanisms involved in the systemic Inflammation, and cytokine storm in COVID-19 patients are still not fully understood. MicroRNA-155 (miR-155) plays a role in the post-transcriptional gene regulation of hematopoiesis, oncogenesis, and Inflammation. The present study aimed to evaluate the expression of miR-155 in patients with DLBCL and/or COVID-19. Methods: A cross-sectional study was conducted from July to December 2020 in Tehran (Iran) to evaluate the expression of miR-155 in adult patients diagnosed with DLBCL and/or COVID-19. The real-time Polymerase chain reaction technique was used to evaluate the expression of miR-155 in the sera of 92 adults who were either healthy or suffering from DLBCL and/or COVID-19. Relative quantification of gene expression was calculated in terms of cycle threshold (Ct) value. Data were analyzed using SPSS software, and P<0. 05 was considered statistically significant. Results: The expression of miR-155 was not associated with the sex or age of the participants. In comparison with healthy individuals (-Δ, Ct:-1. 92±, 0. 25), the expression of miR-155 increased in patients with COVID-19 (1. 95±, 0. 14), DLBCL (2. 25±, 0. 16), or both (4. 33±, 0. 65). Conclusion: The expression of miR-155 increased in patients with DLBCL and/or COVID-19.

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    APA: Copy

    Mahdavi Anari, Seyed Rasool, KHEIRKHAH, BABAK, AMINI, KUMARSS, & ROOZAFZAI, FARZIN. (2023). Expression of MicroRNA-155 in Patients with Non-Hodgkin Lymphoma, Coronavirus Disease 2019, or Both: A Cross-Sectional Study. IRANIAN JOURNAL OF MEDICAL SCIENCES (IJMS), 48(1), 26-34. SID. https://sid.ir/paper/1091607/en

    Vancouver: Copy

    Mahdavi Anari Seyed Rasool, KHEIRKHAH BABAK, AMINI KUMARSS, ROOZAFZAI FARZIN. Expression of MicroRNA-155 in Patients with Non-Hodgkin Lymphoma, Coronavirus Disease 2019, or Both: A Cross-Sectional Study. IRANIAN JOURNAL OF MEDICAL SCIENCES (IJMS)[Internet]. 2023;48(1):26-34. Available from: https://sid.ir/paper/1091607/en

    IEEE: Copy

    Seyed Rasool Mahdavi Anari, BABAK KHEIRKHAH, KUMARSS AMINI, and FARZIN ROOZAFZAI, “Expression of MicroRNA-155 in Patients with Non-Hodgkin Lymphoma, Coronavirus Disease 2019, or Both: A Cross-Sectional Study,” IRANIAN JOURNAL OF MEDICAL SCIENCES (IJMS), vol. 48, no. 1, pp. 26–34, 2023, [Online]. Available: https://sid.ir/paper/1091607/en

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