مرکز اطلاعات علمی Scientific Information Database (SID) - Trusted Source for Research and Academic Resources

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Information Journal Paper

Title

Immunogenic Potential of the Mediterranean Fever Gene in Patients with Coronavirus Disease: A Cross-Sectional Study

Pages

  43-48

Abstract

 Background: In December 2019, an outbreak of pneumonia caused by the novel coronavirus disease 2019 (COVID-19) became a pandemic and caused a global health crisis. This study evaluates the immunogenic potential of the Mediterranean fever (MEFV) gene in patients with COVID-19. Methods: A cross-sectional study was conducted from March to April 2020 in various COVID-19 referral centers in Ardabil, Iran. Blood samples of 50 hospitalized patients with confirmed COVID-19 were evaluated for MEFV gene mutation using the amplification refractory mutation system polymerase chain reaction (ARMS-PCR) and Sanger sequencing. Statistical analysis was performed using SPSS software, version 22. 0. Results: Mutations of the MEFV gene were found in 6 (12%) of the patients. All mutations were heterozygous, and no homozygous or compound heterozygous forms were detected. The total mutant allele frequency was 6% and the carrier rate was 12%. The most common allele of the MEFV variant was E148Q, detected in 3 (6%) patients. No mutant variant of the MEFV gene was detected in deceased patients. None of the mutation carriers had Familial Mediterranean fever (FMF) symptoms or a family history of FMF. Conclusion: MEFV gene mutations may have immunogenic potential in patients with COVID-19. A preprint version of this article has already been published at https: //www. researchsquare. com/article/rs-69373/latest. pdf.

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    APA: Copy

    SALEHZADEH, FARHAD, POURFARZI, FARHAD, MOLATEFI, RASOOL, Davarnia, Behzad, Shahbazfar, Ehsan, & AHMADABADI, FARZAD. (2023). Immunogenic Potential of the Mediterranean Fever Gene in Patients with Coronavirus Disease: A Cross-Sectional Study. IRANIAN JOURNAL OF MEDICAL SCIENCES (IJMS), 48(1), 43-48. SID. https://sid.ir/paper/1091614/en

    Vancouver: Copy

    SALEHZADEH FARHAD, POURFARZI FARHAD, MOLATEFI RASOOL, Davarnia Behzad, Shahbazfar Ehsan, AHMADABADI FARZAD. Immunogenic Potential of the Mediterranean Fever Gene in Patients with Coronavirus Disease: A Cross-Sectional Study. IRANIAN JOURNAL OF MEDICAL SCIENCES (IJMS)[Internet]. 2023;48(1):43-48. Available from: https://sid.ir/paper/1091614/en

    IEEE: Copy

    FARHAD SALEHZADEH, FARHAD POURFARZI, RASOOL MOLATEFI, Behzad Davarnia, Ehsan Shahbazfar, and FARZAD AHMADABADI, “Immunogenic Potential of the Mediterranean Fever Gene in Patients with Coronavirus Disease: A Cross-Sectional Study,” IRANIAN JOURNAL OF MEDICAL SCIENCES (IJMS), vol. 48, no. 1, pp. 43–48, 2023, [Online]. Available: https://sid.ir/paper/1091614/en

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