Association of Human Leukocyte Antigen Alleles with Carbamazepine-or LamotrigineInduced Stevens-Johnson Syndrome and Toxic Epidermal Necrolysis in an Iranian Population: A Case-control Study

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DASTGHEIB LADAN; Rostami Farima; GHARESI FARD BEHROUZ; ASADI POOYA ALI AKBAR; Namjoo Saba; Tahmasebi Foroozan; HADIBARHAGHTALAB MARYAM

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Journal: IRANIAN JOURNAL OF MEDICAL SCIENCES (IJMS) Year:2023 | Volume:48 | Issue:1 Page(s): 70-76

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Title

Association of Human Leukocyte Antigen Alleles with Carbamazepine-or LamotrigineInduced Stevens-Johnson Syndrome and Toxic Epidermal Necrolysis in an Iranian Population: A Case-control Study

Author(s)

Keywords

Stevens-Johnson syndrome

Anticonvulsants

Histocompatibility testing

Abstract

Background: Genetic diversity in human leukocyte antigen (HLA) alleles across populations is a significant risk factor for drug-induced severe cutaneous adverse reactions (SCARs), e. g., carbamazepine (CBZ)-and lamotrigine (LTG)-induced StevensJohnson syndrome (SJS), and toxic epidermal necrolysis (TEN). The present study aimed to investigate the frequency of different HLA alleles in Iranian patients with CBZ-and LTG-induced SJS/TEN. Methods: A case-control study was conducted from 2011 to 2018 at various hospitals affiliated with Shiraz University of Medical Sciences (Shiraz, Iran). A total of 31 patients receiving anticonvulsant drugs (CZB or LTG) were recruited and divided into two groups. The drug-induced group (n=14) included hospitalized patients due to CBZ-or LTG-induced SJS/TEN. The drug-tolerant group (n=17) included individuals receiving CBZ or LTG for at least three months with no adverse effects. In addition, 46 healthy individuals (control group) were recruited. The frequency of HLA-A,-B, and-DRB1 alleles in patients with CZB-or LTG-induced SJS/TEN was investigated. HLA typing was performed using the allele-specific polymerase chain reaction method. The Chi square test and Fisher’, s exact test were used to determine a potential association between SJS/TEN and HLA alleles. P<0. 05 was considered statistically significant. Results: CBZ-or LTG-induced SJS/TEN was not significantly associated with HLA alleles. However, HLA-DRB1*01 showed a significantly higher frequency in patients with CBZ-induced SJS/TEN than the CBZ-tolerant patients (30% vs. 9%, P=0. 07). Conclusion: Overall, no significant association was found between CBZ-or LTG-induced SJS/TEN and HLA alleles. Further largescale studies are required to substantiate our findings.

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APA: Copy

DASTGHEIB, LADAN, Rostami, Farima, GHARESI FARD, BEHROUZ, ASADI POOYA, ALI AKBAR, Namjoo, Saba, Tahmasebi, Foroozan, & HADIBARHAGHTALAB, MARYAM. (2023). Association of Human Leukocyte Antigen Alleles with Carbamazepine-or LamotrigineInduced Stevens-Johnson Syndrome and Toxic Epidermal Necrolysis in an Iranian Population: A Case-control Study. IRANIAN JOURNAL OF MEDICAL SCIENCES (IJMS), 48(1), 70-76. SID. https://sid.ir/paper/1091617/en

Vancouver: Copy

DASTGHEIB LADAN, Rostami Farima, GHARESI FARD BEHROUZ, ASADI POOYA ALI AKBAR, Namjoo Saba, Tahmasebi Foroozan, HADIBARHAGHTALAB MARYAM. Association of Human Leukocyte Antigen Alleles with Carbamazepine-or LamotrigineInduced Stevens-Johnson Syndrome and Toxic Epidermal Necrolysis in an Iranian Population: A Case-control Study. IRANIAN JOURNAL OF MEDICAL SCIENCES (IJMS)[Internet]. 2023;48(1):70-76. Available from: https://sid.ir/paper/1091617/en

IEEE: Copy

LADAN DASTGHEIB, Farima Rostami, BEHROUZ GHARESI FARD, ALI AKBAR ASADI POOYA, Saba Namjoo, Foroozan Tahmasebi, and MARYAM HADIBARHAGHTALAB, “Association of Human Leukocyte Antigen Alleles with Carbamazepine-or LamotrigineInduced Stevens-Johnson Syndrome and Toxic Epidermal Necrolysis in an Iranian Population: A Case-control Study,” IRANIAN JOURNAL OF MEDICAL SCIENCES (IJMS), vol. 48, no. 1, pp. 70–76, 2023, [Online]. Available: https://sid.ir/paper/1091617/en

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