Multi-Drug Resistance against Second-Line Medication and MicroRNA Plasma Level in Metastatic Breast Cancer Patients

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DEHGHANI MEHDI; Mokhtari Samira; Abidi Hassan; ALIPOOR BEHNAM; NAZER MOZAFFARI MOHAMMAD AMIN; SADEGHI HOSSEIN; MAHMOUDI REZA; NIKSERESHT MOHSEN

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Journal: Iranian Journal of Medical Sciences Year:2023 | Volume:48 | Issue:2 Page(s): 146-155

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Title

Multi-Drug Resistance against Second-Line Medication and MicroRNA Plasma Level in Metastatic Breast Cancer Patients

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Keywords

MicroRNAs

Breast neoplasms

Drug resistance

Neoplasm metastasis

Abstract

Background: Circulating MicroRNAs (miRNAs) can help to predict the chemotherapy response in breast cancer with promising results. The aim of the present study was to investigate the relationships between the miR-199a, miR-663a, and miR663b expression and chemotherapy response in metastatic breast cancer patients. Methods: This study is a case-control study performed at Yasuj University of Medical Sciences (2018-2021). The expression levels of miR-663a, miR-663b, and miR-199a in the serum of 25 patients with metastatic breast cancer versus 15 healthy individuals were determined by the real-time polymerase chain reaction method. The response to treatment was followed up in a 24-month period. All patients were treated with secondline medications. Two or more combinations of these drugs were used: gemcitabine, Navelbine ®, , Diphereline ®, , Xeloda ®, , letrozole, Aromasin ®, , and Zolena ®, . Statistical analyses were performed in SPSS 21. 0 and GraphPad Prism 6 software. The expression levels were presented as mean±, SD and analyzed by Student’, s t test. Results: The results and clinicopathological features of patients were analyzed by t test. The statistical analysis showed that miR663a expression was related to human epidermal growth factor receptor 2 (HER2) status and was significantly lower in the HER2 + than HER2- group (P=0. 027). Moreover, the expression of miR199a and miR-663b was significantly correlated with the response to treatment, in which the expression of miR-199a was higher in the poor-response group (P=0. 049), while the higher expression of miR-663b was seen in the good-response group (P=0. 009). Conclusion: These findings state that the high plasma level of miR-199a and the low plasma level of miR-663b may be related to chemoresistance in patients with metastatic breast cancer.

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APA: Copy

DEHGHANI, MEHDI, Mokhtari, Samira, Abidi, Hassan, ALIPOOR, BEHNAM, NAZER MOZAFFARI, MOHAMMAD AMIN, SADEGHI, HOSSEIN, MAHMOUDI, REZA, & NIKSERESHT, MOHSEN. (2023). Multi-Drug Resistance against Second-Line Medication and MicroRNA Plasma Level in Metastatic Breast Cancer Patients. IRANIAN JOURNAL OF MEDICAL SCIENCES (IJMS), 48(2), 146-155. SID. https://sid.ir/paper/1091853/en

Vancouver: Copy

DEHGHANI MEHDI, Mokhtari Samira, Abidi Hassan, ALIPOOR BEHNAM, NAZER MOZAFFARI MOHAMMAD AMIN, SADEGHI HOSSEIN, MAHMOUDI REZA, NIKSERESHT MOHSEN. Multi-Drug Resistance against Second-Line Medication and MicroRNA Plasma Level in Metastatic Breast Cancer Patients. IRANIAN JOURNAL OF MEDICAL SCIENCES (IJMS)[Internet]. 2023;48(2):146-155. Available from: https://sid.ir/paper/1091853/en

IEEE: Copy

MEHDI DEHGHANI, Samira Mokhtari, Hassan Abidi, BEHNAM ALIPOOR, MOHAMMAD AMIN NAZER MOZAFFARI, HOSSEIN SADEGHI, REZA MAHMOUDI, and MOHSEN NIKSERESHT, “Multi-Drug Resistance against Second-Line Medication and MicroRNA Plasma Level in Metastatic Breast Cancer Patients,” IRANIAN JOURNAL OF MEDICAL SCIENCES (IJMS), vol. 48, no. 2, pp. 146–155, 2023, [Online]. Available: https://sid.ir/paper/1091853/en

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