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Information Journal Paper

Title

Association of Oxidative Stress with Kidney Injury in a Hyperandrogenemic Female Rat Model

Pages

  187-197

Abstract

 Background: Polycystic ovary syndrome (PCOS) is the most common reproductive dysfunction in premenopausal women. PCOS is associated with Oxidative stress (OS), which is the main risk factor for renal diseases. This study aimed to investigate the mechanisms responsible for renal injury in a hyperandrogenemic female rat model. Methods: This study was conducted from December 2019 to September 2021 at Shiraz Nephro-Urology Research Centre, Shiraz University of Medical Sciences (Shiraz, Iran). Thirty female Sprague-Dawley rats were randomly divided into three groups (n=10), namely control, sham, and Dehydroepiandrosterone (DHEA). Plasma total testosterone, plasma creatinine (Cr), and blood urea nitrogen (BUN) levels were measured. In addition, total oxidant status (TOS), total antioxidant capacity (TAC), Oxidative stress index (OSI), and histopathological changes in the ovaries and kidneys were determined. Data were analyzed using the GraphPad Prism software, and P<0. 05 was considered statistically significant. Results: Plasma total testosterone levels increased by ninefold in DHEA-treated rats compared to controls (P=0. 0001). Administration of DHEA increased Cr and BUN levels and caused severe renal tubular cell injury. In addition, plasma and tissue (kidney and ovary) TAC levels decreased significantly, but TOS levels and OSI values were significantly increased (P=0. 019). Significant damage to both glomerular and tubular parts of the kidney and ovarian follicular structure was observed in the DHEA group. Conclusion: Hyperandrogenemia caused systemic abnormalities through OS-related mechanisms and damaged renal and ovarian tissues. DHEA treatment in rat models is recommended to study the mechanisms that mediate PCOS-associated renal injury.

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    Cite

    APA: Copy

    Forghani, Nima, KARIMI, ZEINAB, MOKHTARI, MOKHTAR, SHARIATI, MEHRDAD, & MASJEDI, FATEMEH. (2023). Association of Oxidative Stress with Kidney Injury in a Hyperandrogenemic Female Rat Model. IRANIAN JOURNAL OF MEDICAL SCIENCES (IJMS), 48(2), 187-197. SID. https://sid.ir/paper/1091879/en

    Vancouver: Copy

    Forghani Nima, KARIMI ZEINAB, MOKHTARI MOKHTAR, SHARIATI MEHRDAD, MASJEDI FATEMEH. Association of Oxidative Stress with Kidney Injury in a Hyperandrogenemic Female Rat Model. IRANIAN JOURNAL OF MEDICAL SCIENCES (IJMS)[Internet]. 2023;48(2):187-197. Available from: https://sid.ir/paper/1091879/en

    IEEE: Copy

    Nima Forghani, ZEINAB KARIMI, MOKHTAR MOKHTARI, MEHRDAD SHARIATI, and FATEMEH MASJEDI, “Association of Oxidative Stress with Kidney Injury in a Hyperandrogenemic Female Rat Model,” IRANIAN JOURNAL OF MEDICAL SCIENCES (IJMS), vol. 48, no. 2, pp. 187–197, 2023, [Online]. Available: https://sid.ir/paper/1091879/en

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