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Information Journal Paper

Title

Effect of periodic of resistance training on lipid peroxidation and Tumor necrosis factor-alpha in the heart tissue of male rats exposed to stanazol

Pages

  56-66

Abstract

 Background and Aims: Nowadays, the use of energizing substances has become a complex complicated problem in sports and causes damage to various tissues, on the other hand. However, sports activity has a significant impact on controlling and improving oxidative stress factors and inflammatory indicators. Therefore, this study aimed to investigate the effect of eight-weeks of Resistance Training on lipid peroxidation (Malondialdehyde [MDA]MDA) and Tumor necrosis factor-alpha (TNF-α, ) in the heart tissue of rats exposed to stanazol. Materials and Methods: In this experimental study, 24 male rats with a weight range of 150-200 g and a mean age of 8 weeks were selected and randomly divided into 4 groups (n=6 each), namely 1) control (C), 2) sham (Sh), 3) consumption of stanazol (S), and 4) consumption of stanazol together with Resistance Training (S+RT). During eight weeks, both groups of 3 and 4 received 5 mg/kg stanazol intraperitoneally daily,however, group 4 performed Resistance Training three times a week with an intensity of 30%-100% of their body weight. A one-way variance analysis and Tukey's post hoc test were used to analyze the data (P<0. 05). Results: Stanazol had a significant effect on increasing MDA (P=0. 001) and TNF-α,(P=0. 001) in heart tissue. However, Resistance Training led to a decrease in MDA (P=0. 001) and TNF-α,(P=0. 001) in the heart tissue of rats exposed to stanazol. Conclusion: It seems that the consumption of Anabolic Steroids, especially stanazol, increased stress and MDA and TNF-α,in the heart, while Resistance Training can could improve the increased levels of oxidative stress and inflammatory factorsdecrease its findings.

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    Cite

    APA: Copy

    Shojaeyan, Mojtaba, ABEDI, BAHRAM, & HOSSEINI, SAYED ALI. (2023). Effect of periodic of resistance training on lipid peroxidation and Tumor necrosis factor-alpha in the heart tissue of male rats exposed to stanazol. JOURNAL OF BIRJAND UNIVERSITY OF MEDICAL SCIENCES, 30(1 ), 56-66. SID. https://sid.ir/paper/1094094/en

    Vancouver: Copy

    Shojaeyan Mojtaba, ABEDI BAHRAM, HOSSEINI SAYED ALI. Effect of periodic of resistance training on lipid peroxidation and Tumor necrosis factor-alpha in the heart tissue of male rats exposed to stanazol. JOURNAL OF BIRJAND UNIVERSITY OF MEDICAL SCIENCES[Internet]. 2023;30(1 ):56-66. Available from: https://sid.ir/paper/1094094/en

    IEEE: Copy

    Mojtaba Shojaeyan, BAHRAM ABEDI, and SAYED ALI HOSSEINI, “Effect of periodic of resistance training on lipid peroxidation and Tumor necrosis factor-alpha in the heart tissue of male rats exposed to stanazol,” JOURNAL OF BIRJAND UNIVERSITY OF MEDICAL SCIENCES, vol. 30, no. 1 , pp. 56–66, 2023, [Online]. Available: https://sid.ir/paper/1094094/en

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