Effects of Dimethyl Fumarate on the Karnofsky Performance Status and Serum S100β,Level in Newly Glioblastoma Patients: A Randomized, Phase-II, Placebo, Triple Blinded, Controlled Trial

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Shafizadeh Milad; JANGHOLI EHSAN; Maroufi Seyed Farzad; ROSTAMI MOHSEN; Bereimipour Ahmad; Majidi Shahram; Mohebi Niayesh; KHOSHNEVISAN ALIREZA

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Journal: Galen Medical Journal Year:2022 | Volume:11 | Issue:1 Page(s): 0-0

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Title

Effects of Dimethyl Fumarate on the Karnofsky Performance Status and Serum S100β,Level in Newly Glioblastoma Patients: A Randomized, Phase-II, Placebo, Triple Blinded, Controlled Trial

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Keywords

Glioblastoma

Kanofsky's Performance Status

Dimethyl Fumarate

S100β

Surgical Brain Injury

Abstract

Background: Glioblastoma (GBM) is the most common primary central nervous system malignancy with a low survival without extra logistics. Currently, there is no definitive chemotherapy among the studied options. This study aims to evaluate the neuroprotective effects of Dimethyl Fumarate (DMF) on surgical brain injuries in patients treated for GBM. Materials and Methods: This randomized, phase II, placebo, triple-blinded, controlled trial was performed on 36 patients with a diagnosis of GBM. All the patients received DMF (240 mg, three-times per day) or placebo (with the same shape and administration route) one week before surgery. Also, patients in both groups after the operation received standard treatments (radiotherapy plus chemotherapy). In addition, Kanofsky's Performance Status (KPS) score was evaluated at baseline and one month later. Also, serum S100β,was measured 48 hours before and after surgery. Results: There was no significant difference among DMF and control groups with regard to age, gender, and the extent of resections (P˃, 0. 05). The most adverse event in both groups was a headache. Although the serum S100β,level was not markedly changed after surgery, the mean KPS in the DMF group was higher than in the control group after surgery. Conclusion: The DMF could be a possible good regime for the treatment of GBM,however, questions are raised regarding its efficacy and application for the addition to standard treatment.

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APA: Copy

Shafizadeh, Milad, JANGHOLI, EHSAN, Maroufi, Seyed Farzad, ROSTAMI, MOHSEN, Bereimipour, Ahmad, Majidi, Shahram, Mohebi, Niayesh, & KHOSHNEVISAN, ALIREZA. (2022). Effects of Dimethyl Fumarate on the Karnofsky Performance Status and Serum S100β,Level in Newly Glioblastoma Patients: A Randomized, Phase-II, Placebo, Triple Blinded, Controlled Trial. GALEN MEDICAL JOURNAL, 11(1), 0-0. SID. https://sid.ir/paper/1095580/en

Vancouver: Copy

Shafizadeh Milad, JANGHOLI EHSAN, Maroufi Seyed Farzad, ROSTAMI MOHSEN, Bereimipour Ahmad, Majidi Shahram, Mohebi Niayesh, KHOSHNEVISAN ALIREZA. Effects of Dimethyl Fumarate on the Karnofsky Performance Status and Serum S100β,Level in Newly Glioblastoma Patients: A Randomized, Phase-II, Placebo, Triple Blinded, Controlled Trial. GALEN MEDICAL JOURNAL[Internet]. 2022;11(1):0-0. Available from: https://sid.ir/paper/1095580/en

IEEE: Copy

Milad Shafizadeh, EHSAN JANGHOLI, Seyed Farzad Maroufi, MOHSEN ROSTAMI, Ahmad Bereimipour, Shahram Majidi, Niayesh Mohebi, and ALIREZA KHOSHNEVISAN, “Effects of Dimethyl Fumarate on the Karnofsky Performance Status and Serum S100β,Level in Newly Glioblastoma Patients: A Randomized, Phase-II, Placebo, Triple Blinded, Controlled Trial,” GALEN MEDICAL JOURNAL, vol. 11, no. 1, pp. 0–0, 2022, [Online]. Available: https://sid.ir/paper/1095580/en

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