Neuroprotective Effects of Allicin on Neurological Scores, Blood Brain Barrier Permeability and Brain Edema Following Severe Traumatic Brain Injury in Male Rats: A Behavioral, Biochemical and Histological Study

Q: How can I download an article?

To download an article from SID, first log in to the site, search for the article title, and click on the 'Download Article' option.

Q: How can I download an ISI article?

To download an ISI article on SID, enter the keyword or article title in the search bar, view the relevant results, click on the desired article, and select the 'Download Article' option.

Q: How can I access the SID database?

To access the SID database, visit SID.ir, create an account, and log in to access scientific resources.

Q: Is downloading articles from SID free?

Some articles on SID are available for free, while others require payment. Details are specified on the article's page.

Seyedin Seyed Reza; MOHAMMADI MOSLEM; SIAHPOSHT KHACHAKI ALI

مرکز اطلاعات علمی Scientific Information Database (SID) - Trusted Source for Research and Academic Resources

Journal Paper

Paper Information

Journal: Journal of Mazandaran University of Medical Sciences Year:2023 | Volume:32 | Issue:216 Page(s): 61-75

Download Full-Text

View:

Download:

Cites:

Information Journal Paper

Title

Neuroprotective Effects of Allicin on Neurological Scores, Blood Brain Barrier Permeability and Brain Edema Following Severe Traumatic Brain Injury in Male Rats: A Behavioral, Biochemical and Histological Study

Author(s)

Seyedin Seyed Reza | MOHAMMADI MOSLEM | SIAHPOSHT KHACHAKI ALI | Issue Writer Certificate

Keywords

allicin

neuroprotective

brain trauma

brain edema

blood-brain barrier

interleukins

Abstract

Background and purpose: allicin has a wide range of pharmacological functions, all of which can be demonstrated in anti-inflammatory, antioxidant, antifungal and anti-tumor activities. In this research, we investigated the neuroprotective role of allicin in the process of diffuse traumatic brain injury and its effect on interleukin levels and histological changes in rats. Materials and methods: In this experimental study, Wistar rats (n=56) underwent diffuse controlled brain injury by Marmarou method, and 30 minutes later, the drug was injected intraperitoneally at different doses. Veterinary Coma Scale was used and Beam Walk and Beam Balance movement and balance tests were taken at pre-traumatic times, immediately after recovery from the trauma, and 24, 48, and 72 hours after the trauma. Results: Findings showed that allicin at 25 mg/kg and 50 mg/kg can reduce these differences compared to the control group (Sham and Intact) (P<0. 001). allicin was found to be more effective at 25 mg/kg (P<0. 0001). Conclusion: allicin showed neuroprotective effects in the brain and can affect the consequences of trauma, reduce cerebral edema, accelerate improvement of blood-brain barrier, and improve neurological scores and the function of vestibular system.

Cites

No record.

References

No record.

Cite

APA: Copy

Seyedin, Seyed Reza, MOHAMMADI, MOSLEM, & SIAHPOSHT KHACHAKI, ALI. (2023). Neuroprotective Effects of Allicin on Neurological Scores, Blood Brain Barrier Permeability and Brain Edema Following Severe Traumatic Brain Injury in Male Rats: A Behavioral, Biochemical and Histological Study. JOURNAL OF MAZANDARAN UNIVERSITY OF MEDICAL SCIENCES, 32(216 ), 61-75. SID. https://sid.ir/paper/1096350/en

Vancouver: Copy

Seyedin Seyed Reza, MOHAMMADI MOSLEM, SIAHPOSHT KHACHAKI ALI. Neuroprotective Effects of Allicin on Neurological Scores, Blood Brain Barrier Permeability and Brain Edema Following Severe Traumatic Brain Injury in Male Rats: A Behavioral, Biochemical and Histological Study. JOURNAL OF MAZANDARAN UNIVERSITY OF MEDICAL SCIENCES[Internet]. 2023;32(216 ):61-75. Available from: https://sid.ir/paper/1096350/en

IEEE: Copy

Seyed Reza Seyedin, MOSLEM MOHAMMADI, and ALI SIAHPOSHT KHACHAKI, “Neuroprotective Effects of Allicin on Neurological Scores, Blood Brain Barrier Permeability and Brain Edema Following Severe Traumatic Brain Injury in Male Rats: A Behavioral, Biochemical and Histological Study,” JOURNAL OF MAZANDARAN UNIVERSITY OF MEDICAL SCIENCES, vol. 32, no. 216 , pp. 61–75, 2023, [Online]. Available: https://sid.ir/paper/1096350/en

Related Journal Papers

No record.

Related Seminar Papers

No record.

Related Plans

No record.

Recommended Workshops