مرکز اطلاعات علمی Scientific Information Database (SID) - Trusted Source for Research and Academic Resources

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Information Journal Paper

Title

Protective Effect of Continuous Aerobic Training and Crocin on Doxorubicin-Induced Apoptosis in the Heart Tissue of Rats

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  0-0

Abstract

 Background: Doxorubicin (DOX) is widely used to treat various cancers, but its cardio-toxicity restricts its therapeutic application. Objectives: This study aimed to investigate the effect of 8 weeks of Continuous Aerobic Training (CAT) and administration of Crocin (Cr) on the apoptotic index and the expression of Bax and Bcl-2 genes on the DOX-induced cardio-toxicity of rats. Methods: In this experimental study, 50 male Wistar rats were randomly divided into 5 groups, including control, DOX, DOX + CAT, DOX + Cr, and DOX + CAT + Cr groups. Continuous Aerobic Training consisted of 60 minutes of running with the intensity of 40%-60% of maximum speed (5 days/week). Apoptotic index and the expression levels of Bax and Bcl-2 genes were determined in the heart tissue. Results: Doxorubicin significantly increased Bax gene expression in the heart tissue of animals (P < 0. 001). In contrast, Bcl-2 gene expression significantly decreased (P < 0. 001). In all experimental groups, the Bax/Bcl-2 ratio and the percentage of the terminal deoxynucleotidal transferase-mediated biotin-deoxyuridine triphosphate nick-end labeling (TUNEL)-positive cells were significantly diminished compared to the DOX-intoxicated animals. Among experimental groups, CAT had more antiapoptotic effects against DOX-induced cardiac toxicity. Conclusions: Continuous Aerobic Training and Cr, alone or in combination, could attenuate DOX-induced Cardiotoxicity by suppressing Apoptosis in the rats.

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References

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APA: Copy

Shekarriz, Hekmat, Galedari, Mohammad, NIKBAKHT, MASOUD, & KHORSANDI, LAYASADAT. (2022). Protective Effect of Continuous Aerobic Training and Crocin on Doxorubicin-Induced Apoptosis in the Heart Tissue of Rats. JENTASHAPIR JOURNAL OF CELLULAR AND MOLECULAR BIOLOGY (JENTASHAPIR JOURNAL OF HEALTH RESEARCH), 13(3), 0-0. SID. https://sid.ir/paper/1096904/en

Vancouver: Copy

Shekarriz Hekmat, Galedari Mohammad, NIKBAKHT MASOUD, KHORSANDI LAYASADAT. Protective Effect of Continuous Aerobic Training and Crocin on Doxorubicin-Induced Apoptosis in the Heart Tissue of Rats. JENTASHAPIR JOURNAL OF CELLULAR AND MOLECULAR BIOLOGY (JENTASHAPIR JOURNAL OF HEALTH RESEARCH)[Internet]. 2022;13(3):0-0. Available from: https://sid.ir/paper/1096904/en

IEEE: Copy

Hekmat Shekarriz, Mohammad Galedari, MASOUD NIKBAKHT, and LAYASADAT KHORSANDI, “Protective Effect of Continuous Aerobic Training and Crocin on Doxorubicin-Induced Apoptosis in the Heart Tissue of Rats,” JENTASHAPIR JOURNAL OF CELLULAR AND MOLECULAR BIOLOGY (JENTASHAPIR JOURNAL OF HEALTH RESEARCH), vol. 13, no. 3, pp. 0–0, 2022, [Online]. Available: https://sid.ir/paper/1096904/en

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