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Information Journal Paper

Title

Protective Effect of Epicatechin on Survival of PC12 Neurons Exposed to Valproic Acid

Pages

  31-42

Abstract

 Background and purpose: It is well established that valproic acid (VPA) is teratogenic associated with oxidative stress in humans and in all animal species tested. In this study, considering the chemical composition of catechins, we investigated its protective effect on the survival of PC12 nerve cells exposed to valproic acid. Materials and methods: The protective effects of epicatechin (EC) at different concentrations (10, 50, 100, 500, 1000 μ, g/ml) on survival and viability of PC12 neuronal cells exposed to valproic acid were measured by MTT assay and oxidative stress tests (GPx, SOD, ROS, and lipid peroxidation). All data were analyzed in GraphPad Prism 8. 0 using one-way ANOVA and Tukey post-test. Results: According to findings, EC reduced the cytotoxic effects of valproic acid at 500 and 1000 µ, g/ml (P<0. 0001). EC significantly reduced the oxidative stress induced by valproic acid via decreasing reactive oxygen species (ROS) and malondialdehyde (MDA) production (P<0. 001 and P<0. 0001, respectively). Conclusion: The present study showed that epicatechin could increase antioxidant potential and exhibits significant cytoprotective effect against valproic acid toxicity in PC12 cells.

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    APA: Copy

    SHOKRZADEH, MOHAMMAD, MOHAMMAD POUR, ABBAS, TAJIK, ZAHRA, ALIZADEH, MARYAM, & Aghajanshakeri, Shaghayegh. (2023). Protective Effect of Epicatechin on Survival of PC12 Neurons Exposed to Valproic Acid. JOURNAL OF MAZANDARAN UNIVERSITY OF MEDICAL SCIENCES, 33(220 ), 31-42. SID. https://sid.ir/paper/1097629/en

    Vancouver: Copy

    SHOKRZADEH MOHAMMAD, MOHAMMAD POUR ABBAS, TAJIK ZAHRA, ALIZADEH MARYAM, Aghajanshakeri Shaghayegh. Protective Effect of Epicatechin on Survival of PC12 Neurons Exposed to Valproic Acid. JOURNAL OF MAZANDARAN UNIVERSITY OF MEDICAL SCIENCES[Internet]. 2023;33(220 ):31-42. Available from: https://sid.ir/paper/1097629/en

    IEEE: Copy

    MOHAMMAD SHOKRZADEH, ABBAS MOHAMMAD POUR, ZAHRA TAJIK, MARYAM ALIZADEH, and Shaghayegh Aghajanshakeri, “Protective Effect of Epicatechin on Survival of PC12 Neurons Exposed to Valproic Acid,” JOURNAL OF MAZANDARAN UNIVERSITY OF MEDICAL SCIENCES, vol. 33, no. 220 , pp. 31–42, 2023, [Online]. Available: https://sid.ir/paper/1097629/en

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