Antihypoxic Activities of Coenzyme Q and Folic Acid in Asphyctic, Hemic, and Circulatory Hypoxia Models in Mice

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Modammadyan Mahsa; Motafeghi Farzaneh; EGHBALI MOHAMMAD; EBRAHIMZADEH MOHAMMAD ALI

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Journal Paper

Paper Information

Journal: Journal of Mazandaran University of Medical Sciences Year:2023 | Volume:33 | Issue:221 Page(s): 126-131

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Information Journal Paper

Title

Antihypoxic Activities of Coenzyme Q and Folic Acid in Asphyctic, Hemic, and Circulatory Hypoxia Models in Mice

Author(s)

Modammadyan Mahsa | Motafeghi Farzaneh | EGHBALI MOHAMMAD | EBRAHIMZADEH MOHAMMAD ALI | Issue Writer Certificate

Keywords

asphyctic hypoxia

hemic hypoxia

circulatory hypoxia

Coenzyme Q

folic acid

Abstract

Background and purpose: Hypoxia is a decrease in oxygen levels of body tissues which can lead to body function impairment. Coenzyme Q and folic acid are well-known drugs with distinctive antioxidant and anti-ischemic activities, but, nothing is known about antihypoxic activities of these compounds. The current study investigated the antihypoxic activities of Coenzyme Q and folic acid in three experimental models of hypoxia,asphyctic, circulatory, and hemic. Materials and methods: Protective effects of Coenzyme Q at 25, 50, and 100 mg/kg and folic acid at 10, 20, and 40 mg/kg against hypoxia-induced lethality in mice were evaluated by increase in the survival time in asphyctic hypoxia, haemic hypoxia, and circulatory hypoxia models against negative control (normal saline) and positive control (propranolol 30 mg/kg). Analysis of variance was performed followed by Newman-Keuls multiple comparison test to determine the differences between means. Results: Coenzyme Q at 25 mg/kg, in asphyctic and circulating models, showed activities similar to those of propranolol in increasing the survival time (P>0. 05). folic acid at 10 mg/kg, in hemic and circulating models, exhibited activities similar to those of propranolol in increasing the survival time (P>0. 05). Conclusion: Coenzyme Q and folic acid showed good protective effects by increasing the survival time against hypoxia in all models. The effects were dominant, especially in asphyctic and circulating models for Coenzyme Q and in hemic and circulating models for folic acid which led to prolonged survival times. These drugs seem to have a good potential in treatment of hypoxic conditions.

Cites

Evaluation of Antihypoxic Activities of Naringin and Naringenin in Asphyxia, Haemic and Circulatory Hypoxia Models in Mice

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APA: Copy

Modammadyan, Mahsa, Motafeghi, Farzaneh, EGHBALI, MOHAMMAD, & EBRAHIMZADEH, MOHAMMAD ALI. (2023). Antihypoxic Activities of Coenzyme Q and Folic Acid in Asphyctic, Hemic, and Circulatory Hypoxia Models in Mice. JOURNAL OF MAZANDARAN UNIVERSITY OF MEDICAL SCIENCES, 33(221 ), 126-131. SID. https://sid.ir/paper/1098461/en

Vancouver: Copy

Modammadyan Mahsa, Motafeghi Farzaneh, EGHBALI MOHAMMAD, EBRAHIMZADEH MOHAMMAD ALI. Antihypoxic Activities of Coenzyme Q and Folic Acid in Asphyctic, Hemic, and Circulatory Hypoxia Models in Mice. JOURNAL OF MAZANDARAN UNIVERSITY OF MEDICAL SCIENCES[Internet]. 2023;33(221 ):126-131. Available from: https://sid.ir/paper/1098461/en

IEEE: Copy

Mahsa Modammadyan, Farzaneh Motafeghi, MOHAMMAD EGHBALI, and MOHAMMAD ALI EBRAHIMZADEH, “Antihypoxic Activities of Coenzyme Q and Folic Acid in Asphyctic, Hemic, and Circulatory Hypoxia Models in Mice,” JOURNAL OF MAZANDARAN UNIVERSITY OF MEDICAL SCIENCES, vol. 33, no. 221 , pp. 126–131, 2023, [Online]. Available: https://sid.ir/paper/1098461/en

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