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Information Journal Paper

Title

Arsenic Trioxide Affects the Proliferation of Gastric Cancer Cells through MiR-885-5p/CDC73 Axis

Pages

  128-137

Abstract

 Background: To explore Arsenic trioxide (As2O3) and its regulated miR-885-5p/CDC73 signaling pathway involved in the development of Gastric cancer. Methods: Fifty-two healthy patients and patients with Gastric cancer were enrolled 2019-2020 in He Xian Memorial Hospital, Guangzhou, China. The patients with Gastric cancer were divided into control group and As2O3 administration group. After 2 courses of treatment, their peripheral blood was collected to analyze the therapeutic effect. miR-885-5p expression in peripheral blood was analyzed by qRT-PCR. As2O3 was added into MGC-803 Gastric cancer cell line at 0, 10, 20, 40 and 80 μ, mol/L. The proliferation rate and 48h IC50 val-ue of Gastric cancer cells were investigated by CCK-8, and the effect of As2O3 on miR-885-5p expression in the cells was analyzed. Results: After 4 weeks of treatment, the objective efficiency of control group and As2O3 administration group was 17. 3% and 13. 4%, respectively, without significant statistical difference. The overall benefit rate of As2O3 administration group was significantly higher than that of the normal treatment group (P=0. 049). qRT-PCR experiment results found that miR-885-5p significantly highly expressed in peripheral blood in the As2O3 ad-ministration group, while miR-885-5p in Gastric cancer was lower compared with normal people. Adding As2O3 to the Gastric cancer cells could significantly inhibit miR-885-5p expression, while miR-885-5p in Gastric cancer cells affected cell expression by targeted regulation, affecting Cell proliferation. Conclusion: As2O3 may be used as a drug treatment program for Gastric cancer, and mainly regulates the pro-liferation of Gastric cancer cells by affecting the miR-885-5p/CDC73 target axis to participate in the develop-ment of Gastric cancer.

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    Cite

    APA: Copy

    Guo, Xiongbo, & Zhu, Wenbiao. (2023). Arsenic Trioxide Affects the Proliferation of Gastric Cancer Cells through MiR-885-5p/CDC73 Axis. IRANIAN JOURNAL OF PUBLIC HEALTH, 52(1), 128-137. SID. https://sid.ir/paper/1099048/en

    Vancouver: Copy

    Guo Xiongbo, Zhu Wenbiao. Arsenic Trioxide Affects the Proliferation of Gastric Cancer Cells through MiR-885-5p/CDC73 Axis. IRANIAN JOURNAL OF PUBLIC HEALTH[Internet]. 2023;52(1):128-137. Available from: https://sid.ir/paper/1099048/en

    IEEE: Copy

    Xiongbo Guo, and Wenbiao Zhu, “Arsenic Trioxide Affects the Proliferation of Gastric Cancer Cells through MiR-885-5p/CDC73 Axis,” IRANIAN JOURNAL OF PUBLIC HEALTH, vol. 52, no. 1, pp. 128–137, 2023, [Online]. Available: https://sid.ir/paper/1099048/en

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