Clinical Application of MicroRNAs in Breast Cancer Treatment (Review Article)

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Hironaka Mitsuhashi Ai; Takayama Shin; Jimbo Kenjiro; Suto Akihiko; Shimomura Akihiko; Ochiya Takahiro

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Journal Paper

Paper Information

Journal: Archives of Breast Cancer Year:2022 | Volume:9 | Issue:1 Page(s): 20-31

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Title

Clinical Application of MicroRNAs in Breast Cancer Treatment (Review Article)

Author(s)

Keywords

Antineoplastic agents

biomarkers

breast neoplasms

extracellular vesicle

microRNAs

Abstract

Background: Recurrence of breast cancer remains a critical problem. Therefore, it is imperative to identify biomarkers that accurately reflect disease state and develop novel drug therapies that are effective even after recurrence. microRNAs (miRNAs) are involved in the malignant transformation of various tumors. Circulating miRNAs are promising biomarkers for the diagnosis and treatment of cancers. Additionally, miRNAs are regarded as next-generation drug targets. Currently, various clinical trials are being conducted for anti-cancer drugs using miRNAs. In this review, we summarized recent studies on miRNA functions and circulating miRNAs in breast cancer, and discussed the status of miRNAs as drug discovery candidates. We also discussed the role of extracellular vesicles (EVs) in the clinical application of miRNAs. Methods: Relevant articles published from 2002 to 2021 were acquired from PubMed database using the following key words: “, miRNA”,and “, breast neoplasia”, . Clinical trial data were retrieved from the database, ClinicalTrials. gov. Results: Regulating these miRNAs may provide a new therapeutic strategy. Furthermore, miRNAs may be useful diagnostic and prognostic biomarkers for breast cancer. In addition, miRNAs have potential as anti-cancer agents, and may also be used in combination with other therapies to enhance the efficacies of other drugs. Conclusion: In summary, miRNAs have shown promise as biomarkers and therapeutic targets. In addition, EVs will be the key to expanding the applications of miRNAs.

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APA: Copy

Hironaka Mitsuhashi, Ai, Takayama, Shin, Jimbo, Kenjiro, Suto, Akihiko, Shimomura, Akihiko, & Ochiya, Takahiro. (2022). Clinical Application of MicroRNAs in Breast Cancer Treatment (Review Article). ARCHIVES OF BREAST CANCER, 9(1), 20-31. SID. https://sid.ir/paper/1099800/en

Vancouver: Copy

Hironaka Mitsuhashi Ai, Takayama Shin, Jimbo Kenjiro, Suto Akihiko, Shimomura Akihiko, Ochiya Takahiro. Clinical Application of MicroRNAs in Breast Cancer Treatment (Review Article). ARCHIVES OF BREAST CANCER[Internet]. 2022;9(1):20-31. Available from: https://sid.ir/paper/1099800/en

IEEE: Copy

Ai Hironaka Mitsuhashi, Shin Takayama, Kenjiro Jimbo, Akihiko Suto, Akihiko Shimomura, and Takahiro Ochiya, “Clinical Application of MicroRNAs in Breast Cancer Treatment (Review Article),” ARCHIVES OF BREAST CANCER, vol. 9, no. 1, pp. 20–31, 2022, [Online]. Available: https://sid.ir/paper/1099800/en

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