Evaluation of Antihypoxic Activities of Colchicine

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Barani Amin; Khanalipour Mohammad Hossein; Dalilian Nasim; FARZIN DAVOOD; EBRAHIMZADEH MOHAMMAD ALI

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Journal Paper

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Journal: Journal of Mazandaran University of Medical Sciences Year:2023 | Volume:33 | Issue:224 Page(s): 129-137

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Title

Evaluation of Antihypoxic Activities of Colchicine

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Keywords

asphyctic hypoxia

haemic hypoxia

circulatory hypoxia

antioxidant

colchicine

Abstract

Background and purpose: Hypoxia can lead to body function impairment. It is linked to the pathology of acute mountain sickness, cardiovascular disease, and stroke. colchicine, an antiinflammatory drug, is used chiefly in treatment of gout, but it is also valuable in other inflammatory conditions. Preliminary data shows that colchicine has beneficial effects on COVID-19. Nothing is known about the protective effect of this drug against hypoxia-induced lethality in mice. Materials and methods: Protective effects of colchicine against hypoxia-induced lethality in mice at 0. 5, 1, and 1. 5 mg/kg, P. O. were evaluated in three experimental models of hypoxia. Results: colchicine showed good activity in some models. In the circulatory model, at 0. 5 mg/kg, it significantly prolonged mice survival time for 4. 5 min (P<0. 05). At this dose, it showed similar activity to propranolol 30 mg/kg which was used as the positive control. At 1. 5 mg/kg, it was more effective than propranolol (P<0. 0001). In the haemic antihypoxic model, colchicine at 1 mg/kg, significantly increased survival time and showed the same activity as propranolol (P>0. 05). In the asphyctic model, colchicine did not show any activity. Conclusion: colchicine showed good protective effects against hypoxia in circulatory and haemic models where the drug at 1. 5 mg/kg, was more effective than the positive control, propranolol at 30 mg/kg.

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APA: Copy

Barani, Amin, Khanalipour, Mohammad Hossein, Dalilian, Nasim, FARZIN, DAVOOD, & EBRAHIMZADEH, MOHAMMAD ALI. (2023). Evaluation of Antihypoxic Activities of Colchicine. JOURNAL OF MAZANDARAN UNIVERSITY OF MEDICAL SCIENCES, 33(224 ), 129-137. SID. https://sid.ir/paper/1099814/en

Vancouver: Copy

Barani Amin, Khanalipour Mohammad Hossein, Dalilian Nasim, FARZIN DAVOOD, EBRAHIMZADEH MOHAMMAD ALI. Evaluation of Antihypoxic Activities of Colchicine. JOURNAL OF MAZANDARAN UNIVERSITY OF MEDICAL SCIENCES[Internet]. 2023;33(224 ):129-137. Available from: https://sid.ir/paper/1099814/en

IEEE: Copy

Amin Barani, Mohammad Hossein Khanalipour, Nasim Dalilian, DAVOOD FARZIN, and MOHAMMAD ALI EBRAHIMZADEH, “Evaluation of Antihypoxic Activities of Colchicine,” JOURNAL OF MAZANDARAN UNIVERSITY OF MEDICAL SCIENCES, vol. 33, no. 224 , pp. 129–137, 2023, [Online]. Available: https://sid.ir/paper/1099814/en

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