SERUM LEVELS OF INTERLEUKIN (IL)-17 IN PATIENTS WITH ACUTE MYOCARDIAL INFARCTION AND UNSTABLE ANGINA

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JAFARZADEH ABD ELAH; ESMAEILI NADIMI ALI; NOUGH H.; GOLSHIRI A.; NAKHAEI MARYAM; DALIR B.; REZAYATI M.T.; HASANSHAHI GH.H.; SAYADI ANARI AHMAD REZA

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Journal: Razi Journal of Medical Sciences Year:2009 | Volume:16 | Issue:62 Page(s): 99-104

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Title

SERUM LEVELS OF INTERLEUKIN (IL)-17 IN PATIENTS WITH ACUTE MYOCARDIAL INFARCTION AND UNSTABLE ANGINA

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Keywords

ACUTE MYOCARDIAL INFARCTIONQ3

UNSTABLE ANGINAQ3

IL-17Q1

Abstract

Background and Aim: Recent evidences suggest new risk factors especially inflammatory reactions and immunologic factors may play an important role in the pathogenesis of cardiovascular diseases. The aim of this study was to evaluate the serum levels of IL-17 in patients with ACUTE MYOCARDIAL INFARCTION and UNSTABLE ANGINA.Materials and Methods: In this descriptive study serum samples were obtained from 30 patients with Acute Mycrordial Infarction (MI), 30 patients with UNSTABLE ANGINA (UA) and 30 sex and age matched healthy subjects. Serum samples of participants were tested for the levels of IL-17 by the use of ELISA. Statistical analyses have been done using ANOVA and t-test.Results: The mean serum levels of IL-17 were 6.68±1.2 pg/ml in AMI group, 5.48±1.01 pg/ml in UA group and 2.07±0.60 pg/ml in healthy control group. Statistical analyses showed that the mean serum concentrations of IL-17 in AMI and UA groups was significantly higher than that observed in healthy control group (P<0.005 and P<0.04, respectively). Moreover, the mean serum levels of IL-17 in total IHD (Ischemic Heart Disease) patients (6.08±0.79 pg/ml) was significantly higher than that observed in healthy subjects (P<0.002). No significant difference was observed between AMI and UA groups regarding the mean serum concentrations of IL-17.Conclusion: These results demonstrated higher serum levels of IL-17 in patients with AMI and UA than the control group. Accordingly, IL 17-associated mechanisms may participate in the pathogenesis of IHD.

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APA: Copy

JAFARZADEH, ABD ELAH, ESMAEILI NADIMI, ALI, NOUGH, H., GOLSHIRI, A., NAKHAEI, MARYAM, DALIR, B., REZAYATI, M.T., HASANSHAHI, GH.H., & SAYADI ANARI, AHMAD REZA. (2009). SERUM LEVELS OF INTERLEUKIN (IL)-17 IN PATIENTS WITH ACUTE MYOCARDIAL INFARCTION AND UNSTABLE ANGINA. RAZI JOURNAL OF MEDICAL SCIENCES (JOURNAL OF IRAN UNIVERSITY OF MEDICAL SCIENCES), 16(62), 99-104. SID. https://sid.ir/paper/11011/en

Vancouver: Copy

JAFARZADEH ABD ELAH, ESMAEILI NADIMI ALI, NOUGH H., GOLSHIRI A., NAKHAEI MARYAM, DALIR B., REZAYATI M.T., HASANSHAHI GH.H., SAYADI ANARI AHMAD REZA. SERUM LEVELS OF INTERLEUKIN (IL)-17 IN PATIENTS WITH ACUTE MYOCARDIAL INFARCTION AND UNSTABLE ANGINA. RAZI JOURNAL OF MEDICAL SCIENCES (JOURNAL OF IRAN UNIVERSITY OF MEDICAL SCIENCES)[Internet]. 2009;16(62):99-104. Available from: https://sid.ir/paper/11011/en

IEEE: Copy

ABD ELAH JAFARZADEH, ALI ESMAEILI NADIMI, H. NOUGH, A. GOLSHIRI, MARYAM NAKHAEI, B. DALIR, M.T. REZAYATI, GH.H. HASANSHAHI, and AHMAD REZA SAYADI ANARI, “SERUM LEVELS OF INTERLEUKIN (IL)-17 IN PATIENTS WITH ACUTE MYOCARDIAL INFARCTION AND UNSTABLE ANGINA,” RAZI JOURNAL OF MEDICAL SCIENCES (JOURNAL OF IRAN UNIVERSITY OF MEDICAL SCIENCES), vol. 16, no. 62, pp. 99–104, 2009, [Online]. Available: https://sid.ir/paper/11011/en

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