INVOLVEMENT OF NMDA RECEPTORS IN ANTINOCICEPTIVE EFFECT OF ASCORBIC ACID IN A NEUROPATHIC PAIN MODEL

Q: How can I download an article?

To download an article from SID, first log in to the site, search for the article title, and click on the 'Download Article' option.

Q: How can I download an ISI article?

To download an ISI article on SID, enter the keyword or article title in the search bar, view the relevant results, click on the desired article, and select the 'Download Article' option.

Q: How can I access the SID database?

To access the SID database, visit SID.ir, create an account, and log in to access scientific resources.

Q: Is downloading articles from SID free?

Some articles on SID are available for free, while others require payment. Details are specified on the article's page.

NASIRINEZHAD F.; SAFARPOUR S.

مرکز اطلاعات علمی Scientific Information Database (SID) - Trusted Source for Research and Academic Resources

Journal Paper

Paper Information

Journal: Razi Journal of Medical Sciences Year:2009 | Volume:15 | Issue:60-61 Page(s): 193-204

Download Full-Text

Persian Verion

View:

834

Download:

Cites:

Information Journal Paper

Title

INVOLVEMENT OF NMDA RECEPTORS IN ANTINOCICEPTIVE EFFECT OF ASCORBIC ACID IN A NEUROPATHIC PAIN MODEL

Author(s)

NASIRINEZHAD F. | SAFARPOUR S. | Issue Writer Certificate

Keywords

ASCORBIC ACIDQ2

NMDA RECEPTORQ3

NEUROPATHIC PAINQ3

ANTINOCICEPTIONQ3

Abstract

Background and Aim: Ascorbate (ASCORBIC ACID) is present in high concentration in the nervous system and is released as a result of activation of glutaminergic neurons. Due to high concentration of NMDA RECEPTORs in the nervous system, this study investigated the analgesic efficacy of ASCORBIC ACID (AA) in NEUROPATHIC PAIN condition and the role of NMDA RECEPTORs in this effect.Materials and Methods: In this experimental study, NEUROPATHIC PAIN was induced by chronic constriction injury of sciatic nerve (CCI, model) in the left hind paw. In the second week after CCI, animals received 1, 5, 10 mg/kg of ASCORBIC ACID or normal saline and pain threshold was determined 15 and 30 minutes later. To determine the role of NMDA RECEPTOR in nociceptive effect of AA, separate groups of animals were tested. In these groups in the second week after CCI, 30 min after injection of saline or AA (1 mg/kg) animals received intraperitoneal injection of Ketamin (5 mg/kg) or MK-801 (0.01 mg/kg) and were tested 20 min afterwards. Mechanical allodynia was assessed by Von Frey hairs and mechanical and thermal hyperalgesia were determined by Randall Selitto and Radiant Heat tests, respectively. Data were analyzed by ANOVA and Newman Keuls tests.Results: Intraperitoneal injection of 5 and 10 mg/kg but not 1 mg/kg ASCORBIC ACID increased mechanical and thermal threshold in the second week after CCI. ASCORBIC ACID (1 mg/kg, i.p.) also produced significant inhibition of MK-801 and ketamin - induced ANTINOCICEPTION response. In these groups there was no significant difference in the pain threshold as compared to animals that received normal saline.Conclusion: The results indicate that ASCORBIC ACID produced a dose dependent antinociceptive effect that seems to be mediated through its interaction with NMDA RECEPTORs.

Cites

No record.

References

No record.

Cite

APA: Copy

NASIRINEZHAD, F., & SAFARPOUR, S.. (2009). INVOLVEMENT OF NMDA RECEPTORS IN ANTINOCICEPTIVE EFFECT OF ASCORBIC ACID IN A NEUROPATHIC PAIN MODEL. RAZI JOURNAL OF MEDICAL SCIENCES (JOURNAL OF IRAN UNIVERSITY OF MEDICAL SCIENCES), 15(60-61), 193-204. SID. https://sid.ir/paper/11079/en

Vancouver: Copy

NASIRINEZHAD F., SAFARPOUR S.. INVOLVEMENT OF NMDA RECEPTORS IN ANTINOCICEPTIVE EFFECT OF ASCORBIC ACID IN A NEUROPATHIC PAIN MODEL. RAZI JOURNAL OF MEDICAL SCIENCES (JOURNAL OF IRAN UNIVERSITY OF MEDICAL SCIENCES)[Internet]. 2009;15(60-61):193-204. Available from: https://sid.ir/paper/11079/en

IEEE: Copy

F. NASIRINEZHAD, and S. SAFARPOUR, “INVOLVEMENT OF NMDA RECEPTORS IN ANTINOCICEPTIVE EFFECT OF ASCORBIC ACID IN A NEUROPATHIC PAIN MODEL,” RAZI JOURNAL OF MEDICAL SCIENCES (JOURNAL OF IRAN UNIVERSITY OF MEDICAL SCIENCES), vol. 15, no. 60-61, pp. 193–204, 2009, [Online]. Available: https://sid.ir/paper/11079/en

Related Journal Papers