Is the ChAdOx1 Vaccine Safe and Immunogenic as Prophylactic Measure Against the Lethal Human-Coronaviruses? A Systematic Review

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Alves Cunha de Alcantara Andreia Michelle; Alcantara Barbosa Barros Ivan de; de Souza Prazeres Luiz Paulo; Barros Ivan Barbosa; Mascena Diniz Maia Maria De; Eleuterio de Souza Paulo Roberto

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Journal: ACTA MEDICA IRANICA Year:2023 | Volume:61 | Issue:4 Page(s): 195-203

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Title

Is the ChAdOx1 Vaccine Safe and Immunogenic as Prophylactic Measure Against the Lethal Human-Coronaviruses? A Systematic Review

Author(s)

Keywords

Chimpanzee adenovirus oxford 1 (ChAdOx1)

Vaccine

Coronavirus

Severe acute respiratory syndrome coronavirus 2 (SARS-CoV2)

Middle east respiratory syndrome (MERS-CoV)

Coronavirus disease 2019 (COVID-19)

Abstract

Knowledge of other Coronaviruses has contributed to the development of a Vaccine for the Severe Acute Respiratory Syndrome-Coronavirus-2 (SARS-CoV-2). As soon as the genetic sequence of SARS-CoV2 was released, intense global activity around different Vaccine platform technologies started. Among these platforms, the viral vectored chimpanzee adenovirus Oxford1 (ChAdOx1)-previously studied for various indications, including for the Middle East Respiratory Syndrome Coronavirus (MERS-CoV) Vaccine, and currently is adapted for the ChAdOx1 nCoV-19 (novel Coronavirus-19). Therefore, this systematic review aimed to investigate the potential of the ChAdOx1 platform for the development of a Vaccine for SARS-CoV and MERS-CoV, the Lethal Human-Coronaviruses (Lh-CoVs). For this purpose, a highly sensitive literary search was conducted through electronic databases that reached 1, 445 related articles, of which, eight articles were elected according to previous eligibility criteria. The gathering of the articles demonstrated that the previous approaches, referring to the ChAdox1 platform, have contributed to the development of Vaccines against Lh-CoVs and, that thus far, ChAdOx1 (nCoV-19 and MERS) Vaccines are safe and immunogenic. However, it is important to emphasize that further studies are needed to ensure the effectiveness of Vaccines in humans.

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APA: Copy

Alves Cunha de Alcantara, Andreia Michelle, Alcantara Barbosa Barros, Ivan de, de Souza Prazeres, Luiz Paulo, Barros, Ivan Barbosa, Mascena Diniz Maia, Maria De, & Eleuterio de Souza, Paulo Roberto. (2023). Is the ChAdOx1 Vaccine Safe and Immunogenic as Prophylactic Measure Against the Lethal Human-Coronaviruses? A Systematic Review. ACTA MEDICA IRANICA, 61(4), 195-203. SID. https://sid.ir/paper/1111865/en

Vancouver: Copy

Alves Cunha de Alcantara Andreia Michelle, Alcantara Barbosa Barros Ivan de, de Souza Prazeres Luiz Paulo, Barros Ivan Barbosa, Mascena Diniz Maia Maria De, Eleuterio de Souza Paulo Roberto. Is the ChAdOx1 Vaccine Safe and Immunogenic as Prophylactic Measure Against the Lethal Human-Coronaviruses? A Systematic Review. ACTA MEDICA IRANICA[Internet]. 2023;61(4):195-203. Available from: https://sid.ir/paper/1111865/en

IEEE: Copy

Andreia Michelle Alves Cunha de Alcantara, Ivan de Alcantara Barbosa Barros, Luiz Paulo de Souza Prazeres, Ivan Barbosa Barros, Maria De Mascena Diniz Maia, and Paulo Roberto Eleuterio de Souza, “Is the ChAdOx1 Vaccine Safe and Immunogenic as Prophylactic Measure Against the Lethal Human-Coronaviruses? A Systematic Review,” ACTA MEDICA IRANICA, vol. 61, no. 4, pp. 195–203, 2023, [Online]. Available: https://sid.ir/paper/1111865/en

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