COVID-19 and Diabetes.

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Asgharzadeh Vahid; Valiollahzadeh Mir Reza; Taghinejad Zahra; ASGHARZADEH MOHAMMAD; RASHEDI JALIL; MAHDAVI POOR BEHROZ; Jalaei Nobari Hossein; KHALILI AHMAD ALI; Khairy Yousof; Mir Mazhari Amir Ali

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Journal Paper

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Journal: ACTA MEDICA IRANICA Year:2023 | Volume:61 | Issue:5 Page(s): 257-263

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Title

COVID-19 and Diabetes.

Author(s)

Keywords

Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2)

Coronavirus disease 2019 (COVID-19)

Host risk factors

Diabetes

Abstract

Following the discovery of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) in China, it has been transmitted to travelers through respiratory droplets and distributed worldwide. Viral, environmental, and host factors all play a role in getting infected with the virus and having severe forms of the disease named coronavirus disease 2019 (COVID-19). Diabetes is one of the most important Host risk factors in the progression and severity of COVID-19. In Diabetes, hyperglycemia and protein glycosylation increase pro-inflammatory cytokines levels and suppress innate and adaptive immune system by impairing the function of neutrophils, macrophages, and lymphocytes, especially regulatory T lymphocytes. The compromised immune system in diabetic patients makes them vulnerable to infectious diseases like COVID-19. Correspondingly, people with Diabetes are usually treated with angiotensin-converting enzyme (ACE) inhibitors and angiotensin II Type-I receptor blockers (ARBs), which increase ACE2 expression as a receptor for SARS-CoV-2. Thus, diabetic patients are more likely to develop severe forms of COVID-19 and die due to chronic inflammation and impaired immune function.

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APA: Copy

Asgharzadeh, Vahid, Valiollahzadeh, Mir Reza, Taghinejad, Zahra, ASGHARZADEH, MOHAMMAD, RASHEDI, JALIL, MAHDAVI POOR, BEHROZ, Jalaei Nobari, Hossein, KHALILI, AHMAD ALI, Khairy, Yousof, & Mir Mazhari, Amir Ali. (2023). COVID-19 and Diabetes.. ACTA MEDICA IRANICA, 61(5), 257-263. SID. https://sid.ir/paper/1111944/en

Vancouver: Copy

Asgharzadeh Vahid, Valiollahzadeh Mir Reza, Taghinejad Zahra, ASGHARZADEH MOHAMMAD, RASHEDI JALIL, MAHDAVI POOR BEHROZ, Jalaei Nobari Hossein, KHALILI AHMAD ALI, Khairy Yousof, Mir Mazhari Amir Ali. COVID-19 and Diabetes.. ACTA MEDICA IRANICA[Internet]. 2023;61(5):257-263. Available from: https://sid.ir/paper/1111944/en

IEEE: Copy

Vahid Asgharzadeh, Mir Reza Valiollahzadeh, Zahra Taghinejad, MOHAMMAD ASGHARZADEH, JALIL RASHEDI, BEHROZ MAHDAVI POOR, Hossein Jalaei Nobari, AHMAD ALI KHALILI, Yousof Khairy, and Amir Ali Mir Mazhari, “COVID-19 and Diabetes.,” ACTA MEDICA IRANICA, vol. 61, no. 5, pp. 257–263, 2023, [Online]. Available: https://sid.ir/paper/1111944/en

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