Autism Spectrum Disorder is Related to Increasing Intestinal Prevotella That Can Be Regulated by Vitamin A

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XU XIAOOU; ZHANG YUN; ZHANG XIAOJUAN

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Journal Paper

Paper Information

Journal: Iranian Journal of Psychiatry and Behavioral Sciences Year:2023 | Volume:17 | Issue:2 Page(s): 0-0

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Title

Autism Spectrum Disorder is Related to Increasing Intestinal Prevotella That Can Be Regulated by Vitamin A

Author(s)

XU XIAOOU | ZHANG YUN | ZHANG XIAOJUAN | Issue Writer Certificate

Keywords

Autism Spectrum Disorder

Prevotella

Vitamin A

Abstract

Background: Increasing studies suggest that the microbiome-gut-brain axis plays a fundamental role in developing Autism Spectrum Disorder (ASD). Objectives: We aimed to explore biomarkers from gut bacteria in ASD and the dietary Vitamin A (VitA) relationship with intestinal bacteria of autistic children and provide a theoretical basis for dietary regulation of ASD. Methods: Ten autistic children aged 2 to 6 from special training facilities were enrolled from 2017 to 2018. At the same time, 10 healthy children aged 2 to 6 from a kindergarten were collected as a control. All participants were from Chongqing, China. The 16sRNA amplicon sequencing was used to analyze children’, s intestinal bacteria. The serum retinol level was detected by high-performance liquid chromatography (HPLC), and children’, s dietary intake was analyzed using three-day 24-hour dietary recalls. Results: There were signiﬁ, cant diﬀ, erences in alpha diversity between the groups. Also, a higher relative abundance of Prevotellaceae, Prevotella 9, and Roseburia was observed among ASD children. We also found decreases in 9 bacteria (Enterobacteriales, Gammaproteobacteria, Enterobacteriaceae, Clostridiaceae 1, Clostridium sensu stricto 1, Escherichia-Shigella, Bacteroides fragilis, Escherichia coli, and Clostridium neonatale). Dietary VitA intake and serum retinol concentration were lower in the ASD group than in the control group. Meanwhile, serum VitA had a signiﬁ, cantly negative correlation with the abundance of intestinal Prevotella 9. Conclusions: Our study helps identify some bacterial biomarkers for ASD, as in previous reports. Meanwhile, the study suggests that dietary VitA may be involved in the clinical symptoms of ASD by regulating the intestinal bacteria Prevotella. It may provide a new way to treat ASD in the future. Further studies are needed to identify the results by expanding the sample size and developing animal experiments.

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APA: Copy

XU, XIAOOU, ZHANG, YUN, & ZHANG, XIAOJUAN. (2023). Autism Spectrum Disorder is Related to Increasing Intestinal Prevotella That Can Be Regulated by Vitamin A. IRANIAN JOURNAL OF PSYCHIATRY AND BEHAVIORAL SCIENCES (IJPBS), 17(2), 0-0. SID. https://sid.ir/paper/1113043/en

Vancouver: Copy

XU XIAOOU, ZHANG YUN, ZHANG XIAOJUAN. Autism Spectrum Disorder is Related to Increasing Intestinal Prevotella That Can Be Regulated by Vitamin A. IRANIAN JOURNAL OF PSYCHIATRY AND BEHAVIORAL SCIENCES (IJPBS)[Internet]. 2023;17(2):0-0. Available from: https://sid.ir/paper/1113043/en

IEEE: Copy

XIAOOU XU, YUN ZHANG, and XIAOJUAN ZHANG, “Autism Spectrum Disorder is Related to Increasing Intestinal Prevotella That Can Be Regulated by Vitamin A,” IRANIAN JOURNAL OF PSYCHIATRY AND BEHAVIORAL SCIENCES (IJPBS), vol. 17, no. 2, pp. 0–0, 2023, [Online]. Available: https://sid.ir/paper/1113043/en

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