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Title

Symptomatic and Therapeutic Significance of Generalized Anxiety Disorder Comorbidity in Patients with Obsessive-Compulsive Disorder

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Abstract

 Background: Psychiatric disorders frequently accompany comorbid conditions, which can have negative prognostic eff, ects. The etiological and phenomenological distinctions between these conditions may have signifi, cant implications for their therapeutic approach and clinical course. Objectives: Our study aimed to investigate the symptomatic and therapeutic signifi, cance of comorbid generalized Anxiety Disorder (GAD) on Obsessive-Compulsive Disorder (OCD). Methods: This cross-sectional study included OCD patients referred to private and institutional psychiatric clinics in Rasht, Guilan, in 2021. All participants were divided into two groups: those with OCD and those with both OCD and GAD (OCD-GAD). The diagnoses were determined using structured clinical interviews that followed the DSM-5-research version (DSM-5-RV) criteria and included psychiatric histories. Patients were assessed using the Hamilton anxiety rating (HAM) scale, Yale-Brown Obsessive-Compulsive Scale (Y-BOCS), and Global Assessment of Functioning (GAF). The data were analyzed using SPSS version 20. Results: Out of the 146 participants, 80 had only OCD, while 66 had both OCD and GAD. Both groups demonstrated signifi, cant improvements in GAF scores throughout the treatment period (P < 0. 0001),however, there was no signifi, cant diff, erence between the groups in terms of these improvements. The Y-BOCS score was signifi, cantly higher in the OCD group at baseline (P < 0. 0001), and it decreased more during the fi, rst 3 months in the OCD-GAD group (P = 0. 006). The severity of obsessive-compulsive symptoms related to symmetry (P = 0. 014), hoarding (P = 0. 034), taboo thoughts (P = 0. 023), and aggression (P = 0. 002) was signifi, cantly higher in the group with OCD. Both HAM-A and Y-BOCS scores decreased over time, but HAM-A showed a greater decline at the fi, rst follow-up, while Y-BOCS showed a greater decline at the second follow-up. Conclusions: Considering our fi, ndings, OCD-GAD diagnosis is not a unique subcategory of current psychiatric disorders, and it is not necessarily benefi, cial to regard it as such. However, we found that the Comorbidity of GAD did not harm the prognosis of patients with OCD. Further investigations are recommended to evaluate the clinical signifi, cance of OCD-GAD Comorbidity.

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    APA: Copy

    KHALKHALI, MOHAMMADRASOUL, HABIBI, BAHAREH, Eslamdoust Siahestalkhi, Fatemeh, Farrahi, Hassan, Zare, Roghaye, & Khalkhali, Parnian. (2023). Symptomatic and Therapeutic Significance of Generalized Anxiety Disorder Comorbidity in Patients with Obsessive-Compulsive Disorder. IRANIAN JOURNAL OF PSYCHIATRY AND BEHAVIORAL SCIENCES (IJPBS), 17(2), 0-0. SID. https://sid.ir/paper/1113057/en

    Vancouver: Copy

    KHALKHALI MOHAMMADRASOUL, HABIBI BAHAREH, Eslamdoust Siahestalkhi Fatemeh, Farrahi Hassan, Zare Roghaye, Khalkhali Parnian. Symptomatic and Therapeutic Significance of Generalized Anxiety Disorder Comorbidity in Patients with Obsessive-Compulsive Disorder. IRANIAN JOURNAL OF PSYCHIATRY AND BEHAVIORAL SCIENCES (IJPBS)[Internet]. 2023;17(2):0-0. Available from: https://sid.ir/paper/1113057/en

    IEEE: Copy

    MOHAMMADRASOUL KHALKHALI, BAHAREH HABIBI, Fatemeh Eslamdoust Siahestalkhi, Hassan Farrahi, Roghaye Zare, and Parnian Khalkhali, “Symptomatic and Therapeutic Significance of Generalized Anxiety Disorder Comorbidity in Patients with Obsessive-Compulsive Disorder,” IRANIAN JOURNAL OF PSYCHIATRY AND BEHAVIORAL SCIENCES (IJPBS), vol. 17, no. 2, pp. 0–0, 2023, [Online]. Available: https://sid.ir/paper/1113057/en

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