Safety and Efficacy of Paxlovid in COVID-19 Treatment: A Rapid Review

Q: How can I download an article?

To download an article from SID, first log in to the site, search for the article title, and click on the 'Download Article' option.

Q: How can I download an ISI article?

To download an ISI article on SID, enter the keyword or article title in the search bar, view the relevant results, click on the desired article, and select the 'Download Article' option.

Q: How can I access the SID database?

To access the SID database, visit SID.ir, create an account, and log in to access scientific resources.

Q: Is downloading articles from SID free?

Some articles on SID are available for free, while others require payment. Details are specified on the article's page.

MOBINIZADEH MOHAMMADREZA; AKBARISARI ALI; Olyaeemanesh Alireza; MOHAMMADSHAHI MARITA; AHMADNEZHAD ELHAM; ABOEE PARISA; GHARIB NASERI ZAHRA; Fakoorfard Zeinab; SADEGHI RAHELEH

مرکز اطلاعات علمی Scientific Information Database (SID) - Trusted Source for Research and Academic Resources

Journal Paper

Paper Information

Journal: Health Technology Assessment in Action Year:2022 | Volume:6 | Issue:1 Page(s): 0-0

Download Full-Text

View:

Download:

Cites:

Information Journal Paper

Title

Safety and Efficacy of Paxlovid in COVID-19 Treatment: A Rapid Review

Author(s)

Keywords

Paxlovid

Rapid Review

COVID-19

Pandemic

Health Technology Assessment

Abstract

Context: In the first stage of viral replication, COVID-19 may cause a remarkable inflammatory response in patients. Paxlovid is an oral antivirus medicine that functions through the inhibition of one of the essential enzymes to viral replication, called protease. The present study intends to help policymakers decide on using Paxlovid in COVID-19 treatment. Evidence Acquisition: This Rapid Review searched databases including Cochrane, PubMed, and Google Scholar by the end of July 2022. The inclusion criteria were randomized clinical trials investigating the safety and effectiveness of Paxlovid oral medicine at different doses in COVID-19 patients, compared with placebo or other routine care methods. Results: Based on the results (from three studies meeting the inclusion criteria), Paxlovid has no serious side effects, but when used, the patients must be checked for renal and hepatic failure, as well as drug interactions. Patients treated with this medicine within five days after the symptom onset were hospitalized, with 1% (6/607) in the Paxlovid group and 6. 7% (41/612) in the placebo group. Also, no fatalities were reported in the Paxlovid group until day 28, while 10 (1. 6%) patients died in the placebo group. Conclusions: Paxlovid is very effective in outpatient treatment and comes in a combination pack containing nirmatrelvir 150 mg and ritonavir 100 mg film-coated tablets, to be taken twice daily for five days after the symptom onset in adults and children (over 12 years old and a minimum weight of 40 kg) who have mild to moderate symptoms of COVID-19 in order to prevent severe disease, which may lead to hospitalization and death. However, there is high uncertainty about the possibility of drug interactions.

Cites

No record.

References

Cite

APA: Copy

MOBINIZADEH, MOHAMMADREZA, AKBARISARI, ALI, Olyaeemanesh, Alireza, MOHAMMADSHAHI, MARITA, AHMADNEZHAD, ELHAM, ABOEE, PARISA, GHARIB NASERI, ZAHRA, Fakoorfard, Zeinab, & SADEGHI, RAHELEH. (2022). Safety and Efficacy of Paxlovid in COVID-19 Treatment: A Rapid Review. HEALTH TECHNOLOGY ASSESSMENT IN ACTION, 6(1), 0-0. SID. https://sid.ir/paper/1114348/en

Vancouver: Copy

MOBINIZADEH MOHAMMADREZA, AKBARISARI ALI, Olyaeemanesh Alireza, MOHAMMADSHAHI MARITA, AHMADNEZHAD ELHAM, ABOEE PARISA, GHARIB NASERI ZAHRA, Fakoorfard Zeinab, SADEGHI RAHELEH. Safety and Efficacy of Paxlovid in COVID-19 Treatment: A Rapid Review. HEALTH TECHNOLOGY ASSESSMENT IN ACTION[Internet]. 2022;6(1):0-0. Available from: https://sid.ir/paper/1114348/en

IEEE: Copy

MOHAMMADREZA MOBINIZADEH, ALI AKBARISARI, Alireza Olyaeemanesh, MARITA MOHAMMADSHAHI, ELHAM AHMADNEZHAD, PARISA ABOEE, ZAHRA GHARIB NASERI, Zeinab Fakoorfard, and RAHELEH SADEGHI, “Safety and Efficacy of Paxlovid in COVID-19 Treatment: A Rapid Review,” HEALTH TECHNOLOGY ASSESSMENT IN ACTION, vol. 6, no. 1, pp. 0–0, 2022, [Online]. Available: https://sid.ir/paper/1114348/en

Related Journal Papers

No record.

Related Seminar Papers

No record.

Related Plans

No record.

Recommended Workshops