Prognostic Value of The Leuko-Glycemic Index in Acute Myocardial Infarction, a Systematic Review and Meta-Analysis

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SADEGHI ROXANA; Roshdi Dizaji Shayan; Vazirizadeh Mahabadi Mohammad Hossein; SARVEAZAD ARASH; Forouzannia Seyed Ali

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Journal: Archives of Academic Emergency Medicine Year:621 | Volume: | Issue: Page(s): 0-0

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Title

Prognostic Value of The Leuko-Glycemic Index in Acute Myocardial Infarction, a Systematic Review and Meta-Analysis

Author(s)

Keywords

Glycemic index

prognosis

acute coronary syndrome

myocardial ischemia

death

myocardial infarction

Abstract

Introduction: In recent years, studies have provided evidence on the prognostic value of the leuko-Glycemic index (LGI) in acute myocardial infarction (MI), but there is a lack of consensus. In addition, various reported cut-offs for LGI have raised concern regarding its clinical applicability. So, to conclude, through this systematic review and meta-analysis, we aimed to investigate all available evidence on the prognostic value of LGI in acute MI. Methods: Two independent researchers summarized records available in the four main databases of Medline (Via PubMed), Embase, Scopus, and Web of Science until 15 Sep 2022. Articles studying the prognostic value of the LGI in acute MI were included. Finally, sensitivity, specificity, prognostic odds ratio, and the area under the curve (AUC) for LGI were analyzed and reported. Results: Eleven articles were included (3701 patients, 72. 1% male). Based on the analyses, AUC, sensitivity, and specificity for LGI in prediction of mortality following acute MI were 0. 77 (95% CI: 0. 73 to 0. 80), 0. 75 (95% CI: 0. 62 to 0. 84), and 0. 66 (95% CI: 0. 51 to 0. 78), respectively. Positive and negative post-test probability of LGI in prediction of mortality were 21% and 5%, respectively. AUC, sensitivity, and specificity for LGI in prediction of major cardiac complications after acute MI were 0. 81 (95% CI: 0. 77 to 0. 84), 0. 84 (95% CI: 0. 70 to 0. 92), and 0. 64 (95% CI: 0. 49 to 0. 84), respectively. Also, the Positive and negative post-test probability of LGI in this regard were 59% and 13%, respectively. Conclusion: Although the results demonstrated that the LGI could predictmortality and acute cardiac complication afterMI, the low post-test probability of LGI in risk stratification of patients raises questions regarding its applicability. Nevertheless, as most of the available studies have been conducted in the Latino/Hispanic population, further evidence is warranted to generalize the validity of this tool to other racial populations.

Cites

Leuko-Glycemic Index in the Prognosis of Acute Myocardial Infarction, a Cohort Study on Coronary Angiography and Angioplasty Registry

References

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APA: Copy

SADEGHI, ROXANA, Roshdi Dizaji, Shayan, Vazirizadeh Mahabadi, Mohammad Hossein, SARVEAZAD, ARASH, & Forouzannia, Seyed Ali. (2023). Prognostic Value of The Leuko-Glycemic Index in Acute Myocardial Infarction, a Systematic Review and Meta-Analysis. ARCHIVES OF ACADEMIC EMERGENCY MEDICINE (EMERGENCY), 11(1), 0-0. SID. https://sid.ir/paper/1115107/en

Vancouver: Copy

SADEGHI ROXANA, Roshdi Dizaji Shayan, Vazirizadeh Mahabadi Mohammad Hossein, SARVEAZAD ARASH, Forouzannia Seyed Ali. Prognostic Value of The Leuko-Glycemic Index in Acute Myocardial Infarction, a Systematic Review and Meta-Analysis. ARCHIVES OF ACADEMIC EMERGENCY MEDICINE (EMERGENCY)[Internet]. 2023;11(1):0-0. Available from: https://sid.ir/paper/1115107/en

IEEE: Copy

ROXANA SADEGHI, Shayan Roshdi Dizaji, Mohammad Hossein Vazirizadeh Mahabadi, ARASH SARVEAZAD, and Seyed Ali Forouzannia, “Prognostic Value of The Leuko-Glycemic Index in Acute Myocardial Infarction, a Systematic Review and Meta-Analysis,” ARCHIVES OF ACADEMIC EMERGENCY MEDICINE (EMERGENCY), vol. 11, no. 1, pp. 0–0, 2023, [Online]. Available: https://sid.ir/paper/1115107/en

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