EFFECT OF DIETARY OLIVE LEAF EXTRACT ON BRAIN CHOLESTEROL, CHOLESTEROL ESTER AND TRIGLYCERIDE LEVELS AND OF BRAIN EDEMA IN RAT STROKE MODEL

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RABIEI ZAHRA; BIGDELI MOHAMMAD REZA; MOHAGHEGHI FATEMEH; RASOULIAN BAHRAM; SHARIFI ABULGHASEM

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Journal: Razi Journal of Medical Sciences Year:2012 | Volume:19 | Issue:103 Page(s): 18-25

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Title

EFFECT OF DIETARY OLIVE LEAF EXTRACT ON BRAIN CHOLESTEROL, CHOLESTEROL ESTER AND TRIGLYCERIDE LEVELS AND OF BRAIN EDEMA IN RAT STROKE MODEL

Author(s)

Keywords

OLIVE LEAF EXTRACTQ1

CHOLESTEROLQ3

CHOLESTEROL ESTERQ2

TRIGLYCERIDEQ3

BRAIN STROKEQ2

Abstract

Background: Brain injury by transient complete global brain ischemia (cardiac arrest) and regional incomplete brain ischemia (ischemic stroke) afflicts a very large number of patients with death or permanent disability. Recent studies suggest that olive extracts suppress inflammation and reduce stress oxidative injury.Methods: The aim of the study was to evaluate the effect of dietary OLIVE LEAF EXTRACT (OLE) on brain CHOLESTEROL, CHOLESTEROL ester and TRIGLYCERIDE levels as well as brain edema in rat stroke model. Five groups, each consisting of 12 male Wistar rats, were studied. First and second groups (control and sham) received distilled water, while three treatment groups received oral OLIVE LEAF EXTRACT (OLE) for 30 days (50, 75 and 100 mg/kg/day, respectively). Two hours after the last dose, each main group was subdivided to Middle Cerebral Artery Occlusion (MCAO)-operated (n=6) and intact subgroups (n=6) for assessment of neuropathology (brain edema) and brain lipid analysis.Results: The brain CHOLESTEROL, CHOLESTEROL ester and TRIGLYCERIDE levels were greater in experimental groups when compared to controls. OLIVE LEAF EXTRACTs reduced brain edema in experimental groups of 75 and 100 mg/kg/day.Conclusion: Our data suggest that OLE may be cerebroprotective in a rat model of ischemia-reperfusion. Further work is required to extend these observations.

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A REVIEW ON ANTIDEPRESSANT EFFECTS MEDICINAL PLANTS WITH EMPHASIS ON THEIR MECHANISMS OF ACTION

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APA: Copy

RABIEI, ZAHRA, BIGDELI, MOHAMMAD REZA, MOHAGHEGHI, FATEMEH, RASOULIAN, BAHRAM, & SHARIFI, ABULGHASEM. (2012). EFFECT OF DIETARY OLIVE LEAF EXTRACT ON BRAIN CHOLESTEROL, CHOLESTEROL ESTER AND TRIGLYCERIDE LEVELS AND OF BRAIN EDEMA IN RAT STROKE MODEL. RAZI JOURNAL OF MEDICAL SCIENCES (JOURNAL OF IRAN UNIVERSITY OF MEDICAL SCIENCES), 19(103), 18-25. SID. https://sid.ir/paper/11152/en

Vancouver: Copy

RABIEI ZAHRA, BIGDELI MOHAMMAD REZA, MOHAGHEGHI FATEMEH, RASOULIAN BAHRAM, SHARIFI ABULGHASEM. EFFECT OF DIETARY OLIVE LEAF EXTRACT ON BRAIN CHOLESTEROL, CHOLESTEROL ESTER AND TRIGLYCERIDE LEVELS AND OF BRAIN EDEMA IN RAT STROKE MODEL. RAZI JOURNAL OF MEDICAL SCIENCES (JOURNAL OF IRAN UNIVERSITY OF MEDICAL SCIENCES)[Internet]. 2012;19(103):18-25. Available from: https://sid.ir/paper/11152/en

IEEE: Copy

ZAHRA RABIEI, MOHAMMAD REZA BIGDELI, FATEMEH MOHAGHEGHI, BAHRAM RASOULIAN, and ABULGHASEM SHARIFI, “EFFECT OF DIETARY OLIVE LEAF EXTRACT ON BRAIN CHOLESTEROL, CHOLESTEROL ESTER AND TRIGLYCERIDE LEVELS AND OF BRAIN EDEMA IN RAT STROKE MODEL,” RAZI JOURNAL OF MEDICAL SCIENCES (JOURNAL OF IRAN UNIVERSITY OF MEDICAL SCIENCES), vol. 19, no. 103, pp. 18–25, 2012, [Online]. Available: https://sid.ir/paper/11152/en

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