مرکز اطلاعات علمی Scientific Information Database (SID) - Trusted Source for Research and Academic Resources

Persian Verion
مرکز اطلاعات علمی Scientific Information Database (SID) - Trusted Source for Research and Academic Resources

video

مرکز اطلاعات علمی Scientific Information Database (SID) - Trusted Source for Research and Academic Resources

sound

مرکز اطلاعات علمی Scientific Information Database (SID) - Trusted Source for Research and Academic Resources

Persian Version

مرکز اطلاعات علمی Scientific Information Database (SID) - Trusted Source for Research and Academic Resources

View:

55
مرکز اطلاعات علمی Scientific Information Database (SID) - Trusted Source for Research and Academic Resources

Download:

0
مرکز اطلاعات علمی Scientific Information Database (SID) - Trusted Source for Research and Academic Resources

Cites:

Information Journal Paper

Title

Effect of propofol on hippocampal CA2 and CA3 cells in rat model of ischemic/reperfusion

Pages

  389-397

Abstract

 Background: Cerebral ischemia/ reperfusion leads to programmed cell death or planned apoptosis. Hippocampus is a very sensitive tissue to cerebral ischemia. Propofol is an anesthesia that recently the use of this drug as a neuroprotective has been considered. In this study, the effect of Propofol on CA2 and CA3 areas of the Hippocampus following ischemia was investigated. Materials and methods: 24 Wistar Rats were randomly divided into 4 groups, including: control ischemia, experimental and vehicle. The experimental group received 40 mg/ kg of Propofol and the vehicle group received 1 ml normal saline 1 hour before ischemia intraperitoneally. The ischemic model was performed by bilateral closure of the common carotid arteries for 20 minutes then reperfusion was done. 4 days later, all Rats were sacrificed and the hippocampal tissue was examined by Nissl staining method. Data were analyzed using SPSS-25 statistical software by one-way ANOVA and TUKEY test. p<0. 05 was considered as Significant. Results: Ischemia/ reperfusion for 20 minutes caused degeneRation of pyramidal cells in CA2 and CA3 Hippocampus and these neurons showed a significant decrease compared to the control group, but Propofol injection inhibited the decrease in the number of viable cells in these two areas. Conclusion: Propofol can be used as an effective agent in preventing or reducing the complications of stroke alone or with other drugs.

Cites

  • No record.

    • References

    Cite

    APA: Copy

    Rahchamani, Mostafa, MOVASSAGHI, SHABNAM, KERMANIHA, ZAHRA, & SHARIFI, ZAHRA NADIA. (2023). Effect of propofol on hippocampal CA2 and CA3 cells in rat model of ischemic/reperfusion. MEDICAL SCIENCES JOURNAL OF ISLAMIC AZAD UNIVERSITY, 32(4 ), 389-397. SID. https://sid.ir/paper/1115496/en

    Vancouver: Copy

    Rahchamani Mostafa, MOVASSAGHI SHABNAM, KERMANIHA ZAHRA, SHARIFI ZAHRA NADIA. Effect of propofol on hippocampal CA2 and CA3 cells in rat model of ischemic/reperfusion. MEDICAL SCIENCES JOURNAL OF ISLAMIC AZAD UNIVERSITY[Internet]. 2023;32(4 ):389-397. Available from: https://sid.ir/paper/1115496/en

    IEEE: Copy

    Mostafa Rahchamani, SHABNAM MOVASSAGHI, ZAHRA KERMANIHA, and ZAHRA NADIA SHARIFI, “Effect of propofol on hippocampal CA2 and CA3 cells in rat model of ischemic/reperfusion,” MEDICAL SCIENCES JOURNAL OF ISLAMIC AZAD UNIVERSITY, vol. 32, no. 4 , pp. 389–397, 2023, [Online]. Available: https://sid.ir/paper/1115496/en

    Related Journal Papers

  • No record.

    • Related Seminar Papers

  • No record.

    • Related Plans

  • No record.

    • Recommended Workshops






    Move to top
    telegram sharing button
    whatsapp sharing button
    linkedin sharing button
    twitter sharing button
    email sharing button
    email sharing button
    email sharing button
    sharethis sharing button