The Effects of 3-Month Rosuvastatin Adjuvant Therapy on Post Thrombotic Syndrome following Deep Vein Thrombosis,a Randomized Clinical Trial

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PISHGAHI MEHDI; GHANE FARD SHIRIN; Lak Tabriz Rahil; Karimi Toudeshki Kimia; TALEBI ZAHRA

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Journal: Archives of Academic Emergency Medicine Year:621 | Volume: | Issue: Page(s): 0-0

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Title

The Effects of 3-Month Rosuvastatin Adjuvant Therapy on Post Thrombotic Syndrome following Deep Vein Thrombosis,a Randomized Clinical Trial

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Keywords

Venous thrombosis

Postthrombotic syndrome

Rosuvastatin calcium

Rivaroxaban

Warfarin

Anticoagulants

Abstract

Introduction: Statins are known to have anticoagulation and anti-inflammatory effects. This study aimed to investigate the effect of Rosuvastatin in reduction of post thrombotic syndrome (PTS) following deep vein thrombosis (DVT). Methods: In this randomized clinical trial, patients who were diagnosed with DVT of lower extremity were randomly assigned to 4 treatment groups: group 1: Warfarin, group 2: Warfarin + Rosuvastatin, group 3: Rivaroxaban, and group 4: Rivaroxaban + Rosuvastatin. The treatments were followed for 3 months and prevalence of PTS (as primary outcome), as well as the changes in serumlevels of D-dimer and C reactive protein (CRP), and the extent of thrombosis before and after the intervention (as secondary outcomes) were compared between groups. Results: 182 patients with the mean age of 55. 22 ±,4. 1 years finished the trial period (51. 64% male). There was no significant difference between the groups regarding the baseline characteristics. Based on the Brandjes score, 31 (17. 03%) patients had PTS at the end of the study. The occurrence of PTS was significantly lower in the groups taking statins (p<0. 0001). Although the change in the mean difference of legs circumference before and after intervention, were significant in all groups (p < 0. 05), the differences was more prominent in groups 2 and 4 (p < 0. 0001). After 3 months of taking medication, decrease of CRP was more prominent in the statin groups (p = 0. 001), and most cases with normal CRP were in statin groups. Among the patients with the serum D-dimer level above 10000 ng/mL, patients in the statin groups experienced significantly more reduction in D-dimer levels than the other groups (p<0. 001). Conclusion: Rosuvastatin administration in combination with Rivaroxaban or Warfarin significantly reduces the level of inflammatory factors including CRP and D-dimer, compared to patients receiving Anticoagulants alone. Rosuvastatin administration can significantly reduce the incidence of PTS and cause a difference in the size of the lower limbs within 3 months.

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APA: Copy

PISHGAHI, MEHDI, GHANE FARD, SHIRIN, Lak Tabriz, Rahil, Karimi Toudeshki, Kimia, & TALEBI, ZAHRA. (2023). The Effects of 3-Month Rosuvastatin Adjuvant Therapy on Post Thrombotic Syndrome following Deep Vein Thrombosis,a Randomized Clinical Trial. ARCHIVES OF ACADEMIC EMERGENCY MEDICINE (EMERGENCY), 11(1), 0-0. SID. https://sid.ir/paper/1115633/en

Vancouver: Copy

PISHGAHI MEHDI, GHANE FARD SHIRIN, Lak Tabriz Rahil, Karimi Toudeshki Kimia, TALEBI ZAHRA. The Effects of 3-Month Rosuvastatin Adjuvant Therapy on Post Thrombotic Syndrome following Deep Vein Thrombosis,a Randomized Clinical Trial. ARCHIVES OF ACADEMIC EMERGENCY MEDICINE (EMERGENCY)[Internet]. 2023;11(1):0-0. Available from: https://sid.ir/paper/1115633/en

IEEE: Copy

MEHDI PISHGAHI, SHIRIN GHANE FARD, Rahil Lak Tabriz, Kimia Karimi Toudeshki, and ZAHRA TALEBI, “The Effects of 3-Month Rosuvastatin Adjuvant Therapy on Post Thrombotic Syndrome following Deep Vein Thrombosis,a Randomized Clinical Trial,” ARCHIVES OF ACADEMIC EMERGENCY MEDICINE (EMERGENCY), vol. 11, no. 1, pp. 0–0, 2023, [Online]. Available: https://sid.ir/paper/1115633/en

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