Inflammatory Markers and Atherogenic Coefficient: Early Markers of Metabolic Syndrome

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MAHDAVI ROSHAN MARJAN; Shoaibinobarian Nargeskhatoon; Noormohammadi Morvarid; Fakhr Mousavi Aboozar; Savar Rakhsh Amir; SALARI ARSALAN; GHORBANI ZEINAB

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Journal: International Journal of Endocrinology and Metabolism Year:2022 | Volume:20 | Issue:4 Page(s): 00-00

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Title

Inflammatory Markers and Atherogenic Coefficient: Early Markers of Metabolic Syndrome

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Keywords

Hyperlipidemia

Inflammation

Metabolic Syndrome

Obesity

Triglyceride

Abstract

Background: Considering the close link between Metabolic Syndrome (MetSyn) and cardiovascular diseases, considerable attention has been devoted to the identification of their shared underlying pathological mechanisms in recent decades. Objectives: This study aimed to investigate the association between pro-inflammatory factors and newly-diagnosed MetSyn. Methods: This case-control study recruited obese and nonobese individuals who were newly diagnosed with MetSyn (cases, n = 84) and healthy individuals (controls, n = 83). The medical and sociodemographic data of the participants were collected on enrollment. Serum analysis was performed to ascertain the concentrations of tumor necrosis factor-alpha (TNF-, ), C-reactive protein (CRP), fasting blood sugar (FBS), total cholesterol, Triglyceride, high-density lipoprotein cholesterol (HDL-C), low-density lipoprotein cholesterol (LDL-C), and atherogenic coefficient (AC). Multiple regression analysis was carried out to explore the relationship between inflammatory markers and AC with MetSyn odds. The Pearson correlation test was also performed to investigate the correlations between metabolic and inflammatory parameters. Results: Positive relationships were observed between the serum levels of TNF-, and CRP with the odds of MetSyn following controlling for confounders (adjusted odds ratio [AOR] = 1. 32,95% confidence interval [CI]: 1. 01-1. 72,AOR = 1. 29,95% CI: 1. 18-1. 41,respectively, P,0. 03). Additionally, higher AC was accompanied by increased odds of MetSyn (AOR = 1. 98,95% CI: 1. 31-2. 98,P = 0. 001). The Pearson correlation analysis also showed positive correlations between TNF-, levels and serum metabolic abnormalities, including elevated LDL-C, FBS, and AC and lowered HDL-C levels (P ,0. 02). Conclusions: The present results revealed that higher serum concentrations of pro-inflammatory and atherogenic indices, including CRP, TNF-, , and AC, might be associated with elevated odds of newly diagnosed MetSyn regardless of potential confounders, particularly body mass index. The obtained findings might be moderated by the positive correlations observed between serum TNF-, , as the chronic inflammatory state indicator, and impaired lipid and glycemic markers.

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APA: Copy

MAHDAVI ROSHAN, MARJAN, Shoaibinobarian, Nargeskhatoon, Noormohammadi, Morvarid, Fakhr Mousavi, Aboozar, Savar Rakhsh, Amir, SALARI, ARSALAN, & GHORBANI, ZEINAB. (2022). Inflammatory Markers and Atherogenic Coefficient: Early Markers of Metabolic Syndrome. INTERNATIONAL JOURNAL OF ENDOCRINOLOGY AND METABOLISM (IJEM), 20(4), 00-00. SID. https://sid.ir/paper/1120747/en

Vancouver: Copy

MAHDAVI ROSHAN MARJAN, Shoaibinobarian Nargeskhatoon, Noormohammadi Morvarid, Fakhr Mousavi Aboozar, Savar Rakhsh Amir, SALARI ARSALAN, GHORBANI ZEINAB. Inflammatory Markers and Atherogenic Coefficient: Early Markers of Metabolic Syndrome. INTERNATIONAL JOURNAL OF ENDOCRINOLOGY AND METABOLISM (IJEM)[Internet]. 2022;20(4):00-00. Available from: https://sid.ir/paper/1120747/en

IEEE: Copy

MARJAN MAHDAVI ROSHAN, Nargeskhatoon Shoaibinobarian, Morvarid Noormohammadi, Aboozar Fakhr Mousavi, Amir Savar Rakhsh, ARSALAN SALARI, and ZEINAB GHORBANI, “Inflammatory Markers and Atherogenic Coefficient: Early Markers of Metabolic Syndrome,” INTERNATIONAL JOURNAL OF ENDOCRINOLOGY AND METABOLISM (IJEM), vol. 20, no. 4, pp. 00–00, 2022, [Online]. Available: https://sid.ir/paper/1120747/en

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