Association of interleukin-17 and phagosome with healing after acute myocardial infarction

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MOFAZZAL JAHROMI MIRZA ALI; rasoolipoor Kimia; ESTAKHR ZAHRA; MIR HAMED; Rustazadeh Abazar

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Journal Paper

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Journal: Pars Journal of Medical Sciences Year:2022 | Volume:20 | Issue:2 Page(s): 55-61

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Information Journal Paper

Title

Association of interleukin-17 and phagosome with healing after acute myocardial infarction

Author(s)

Keywords

Acute Mocardial Infarction

IL-17

Phagosome

Microarray

Abstract

Introduction: Acute myocardial infarction is one of the main causes of mortality in the worldwide. The aim of the present study is to predict the Association of interleukin (IL)-17 and Phagosome with acute myocardial infarction. Methods and Materials: Microarray data were extracted from National Center for Biotechnology Information (NCBI) and then analyzed by GEO2R and R softwares. The functional analysis of up/down regulation of genes were performed using DAVID and Enrichr data bases. Results: In this study, expression of 208 genes were lower in patients group compared to the controls (Log2FC<-1). In patients’,group, PAQR8, CCR2, CCR5, and ZNF137P genes significantly had lower expression. Although 528 gens, especially NR4A2, GABARAPL1, THBD, NFIL3, and MAFB significantly had more expression compared to the controls (Log2FC>+1). KEGG analysis on gens that increase expression showed that signaling pathways of IL-17 and Phagosome are two pathways in patients with acute myocardial infarction. Conclusion: According to our finding, after acute myocardial infarction, inflammatory pathway like IL-17 signaling recruiting matrix metalloproteinase 9 as a protein involve in repairing acute myocardial infarction damages. Also, the Phagosome activity by major histocompatibility complex class-II (MHC-II) and CD36 signaling pathways, may be played a role in accelerating healing after acute myocardial infarction damages.

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APA: Copy

rasoolipoor, Kimia, ESTAKHR, ZAHRA, & MIR, HAMED. (2022). Association of interleukin-17 and phagosome with healing after acute myocardial infarction. PARS JOURNAL OF MEDICAL SCIENCES (JAHROM MEDICAL JOURNAL), 20(2 ), 55-61. SID. https://sid.ir/paper/1122322/en

Vancouver: Copy

rasoolipoor Kimia, ESTAKHR ZAHRA, MIR HAMED. Association of interleukin-17 and phagosome with healing after acute myocardial infarction. PARS JOURNAL OF MEDICAL SCIENCES (JAHROM MEDICAL JOURNAL)[Internet]. 2022;20(2 ):55-61. Available from: https://sid.ir/paper/1122322/en

IEEE: Copy

Kimia rasoolipoor, ZAHRA ESTAKHR, and HAMED MIR, “Association of interleukin-17 and phagosome with healing after acute myocardial infarction,” PARS JOURNAL OF MEDICAL SCIENCES (JAHROM MEDICAL JOURNAL), vol. 20, no. 2 , pp. 55–61, 2022, [Online]. Available: https://sid.ir/paper/1122322/en

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