Evaluation of the Local Control Rate and Late Toxicity of High-Dose-Rate Interstitial Brachytherapy in Tongue Squamous Cell Carcinoma

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Amiri Iman; Feli Maryam; Bagheri Ali; Shahbazian Hojattollah; Mohammadian Fatemeh

مرکز اطلاعات علمی Scientific Information Database (SID) - Trusted Source for Research and Academic Resources

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Journal: Journal of Iranian Medical Council Year:621 | Volume: | Issue: Page(s): 168-179

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Title

Evaluation of the Local Control Rate and Late Toxicity of High-Dose-Rate Interstitial Brachytherapy in Tongue Squamous Cell Carcinoma

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Keywords

BrachytherapyQ4

Squamous cell carcinomaQ4

Tongue cancerQ4

Abstract

Background: Tongue Squamous cell carcinoma (TSCC) is one of the most consequential oral Squamous cell carcinomas (SCC) worldwide. Methods: This retrospective cross-sectional study was conducted on 29 TSCC patients treated with High Dose Rate Brachytherapy (HDR-BT) with or without External Beam Radiotherapy (EBRT) between 2017-2020. Patients without distant metastasis at the time of treatment and at least one year after completion of Brachytherapy were included. Results: One-year Overall Survival (OS), Disease-Free Survival (DFS), and Local Control Rate (LCR) were 82. 8, 79. 3, and 100%, respectively. 6 patients (20. 7%) had distant metastasis, of which 5 (17. 2%) died. Local recurrence was not observed in any patients, and only one (3. 4%) regional recurrence occurred. The most common late toxicity of HDR-BT was dry mouth (79. 2%) and dysarthria (66. 7%). There were no severe and life-threatening complications (grades 3 and 4) during one year. Also, 79. 2% of the patients had good functional performance. One-year OS, the significant difference between the two groups of HDR-BT with and without EBRT (p=0. 055). Conclusion: Our findings indicated that the HDR-BT increases the OS of TSCC patients more than EBRT without developing grade 3-4 AEs and metastasis. We showed that the mean 3. 2 ±0. 7 Gy of HDR-BT has more OS compared to EBRT.

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