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Information Journal Paper

Title

Effectiveness of Alginate Hydrogel Containing Ganoderma Polysaccharides on Wound Healing in Rat Model

Pages

  734-747

Abstract

 Introduction: Infectious wounds are one of the most important problems of today's society, which lead to a delay in the stages of Wound Healing. Pseudomonas aeruginosa is one of the most common infections in trauma wounds. Ganoderma is an important mushroom with bioactive compounds that are widely used in traditional medicine on P. aeruginosa. This study aimed to assess this mushroom's effectiveness and antimicrobial properties on P. aeruginosa. Methods: The Polysaccharide compound was extracted from the Ganoderma lucidum mushroom by the Soxhlet method and then purified. The determination of concentration and characterization was done by the FTIR method. Then, the effect of Polysaccharide on P. aeruginosa ATCC 9027 was evaluated on MIC and MBC by broth dilution tests. Next, alginate/collagen Polysaccharide hydrogel was synthesized by thermal method, and the toxicity was evaluated on the L929 mouse fibroblast cell line. Fifteen male Wistar rats were randomly divided into control, positive control, and Al/col/Ps. Histopathological changes were studied. Data were analyzed using SPSS 26 and non-parametric Kruskal-Wallis and Mann-Whitney tests. Results: MIC and MBC concentrations of the Polysaccharide compound against Pseudomonas aeruginosa were calculated as 1. 56 and 3. 13 mg/ml, respectively. In this study, the sample cell viability with an acceptable survival rate of > 70% (toxicity < 30-35%) was the same as the control, indicating non-toxicity compared to the control sample. According to wound histopathology, wound closure (86%), fibroblast 18520, hair follicle 4, angiogenesis, collagen, and epidermis were significantly higher in the Al/col/Ps system group compared to the control group. Conclusion: Besides antimicrobial activity against the standard P. aeruginosa, the extracted Polysaccharide plays a significant role in infectious, traumatic wounds. Our results demonstrate that the Al/col/Ps hydrogel system can be recommended as a potential treatment for trauma wound infections.

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    Cite

    APA: Copy

    SHAKERI, FATEMEH, ZABOLI, FATEMEH, FATTAHI, ESMAIL, & BABAVALIAN, HAMID. (2023). Effectiveness of Alginate Hydrogel Containing Ganoderma Polysaccharides on Wound Healing in Rat Model. TRAUMA MONTHLY, 28(1), 734-747. SID. https://sid.ir/paper/1131003/en

    Vancouver: Copy

    SHAKERI FATEMEH, ZABOLI FATEMEH, FATTAHI ESMAIL, BABAVALIAN HAMID. Effectiveness of Alginate Hydrogel Containing Ganoderma Polysaccharides on Wound Healing in Rat Model. TRAUMA MONTHLY[Internet]. 2023;28(1):734-747. Available from: https://sid.ir/paper/1131003/en

    IEEE: Copy

    FATEMEH SHAKERI, FATEMEH ZABOLI, ESMAIL FATTAHI, and HAMID BABAVALIAN, “Effectiveness of Alginate Hydrogel Containing Ganoderma Polysaccharides on Wound Healing in Rat Model,” TRAUMA MONTHLY, vol. 28, no. 1, pp. 734–747, 2023, [Online]. Available: https://sid.ir/paper/1131003/en

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