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Information Journal Paper

Title

Evaluation of the Anti-Inflammatory Properties of D-limonene Compared with Dexamethasone and Ibuprofen in Bovine Synoviocyte

Pages

  1-14

Abstract

 Introduction: Osteoarthritis is a public health concern that leads to disability due to chronic pain, stiffness, sleep disturbance, and depression. D-limonene is a racemic mixture of limonene, a natural cyclic monoterpene, and the major component of the oil extracted from the citrus rind with chemo-preventive and anti-inflammatory activities. The purpose of this study was to investigate the anti-inflammatory properties of Dlimonene compared with dexamethasone and ibuprofen in bovine fibroblast-like synoviocyte cells (BFLSc) as well as Human THP-1 monocyte/macrophage-like cells. Materials and Methods: BFLSc was isolated from the synovial membrane of the metacarpal joint cartilage of an 8-month-old Holstein. THP-1 cells were prepared by the Pasteur Institute of Iran. Cells were cultivated and exposed to 20 ng/ml lipopolysaccharide (LPS) stimulation without, or in the presence of, ibuprofen, dexamethasone, or D-limonene (7. 5μ, g/ml). The gene expressions of cyclooxygenase-2 (COX-2), Interleukin-1β,(IL-1β, ), inducible nitric oxide synthase (iNOS), and Tumor necrosis factor alpha (TNF-α, ) were evaluated by real-time PCR. Concentrations of Nitric Oxide (NO), and Prostaglandin-E2 (PGE2) were measured by ELISA methods. Results: The inhibitory effects of D-limonene included dose-dependent decreases in the expression of iNOS and COX-2 proteins (P < 0. 05). The treated cells secreted increased amounts of COX-2, IL-1β, , iNOS, TNF-α, , NO, and PGE2 in response to LPS stimulation in all conditions. D-limonene quenched the gene expression of COX-2, iL-1β, , iNOS, and TNF-α, , in BFLSc, and the production of PGE2 and NO in monocyte/macrophage cells alike dexamethasone, and ibuprofen. Conclusion: The results obtained in this study show that D-limonene probably exerts anti-inflammatory effects through the suppression of TNF-α, , IL-1β, , COX-2, and iNOS and NO, PGE2 production.

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    APA: Copy

    MAGHSOUDI, HOSSEIN, & Yazadanpanah, Enayatollah. (2023). Evaluation of the Anti-Inflammatory Properties of D-limonene Compared with Dexamethasone and Ibuprofen in Bovine Synoviocyte. JOURNALS OF BASIC RESEARCH IN MEDICAL SCIENCES, 10(1), 1-14. SID. https://sid.ir/paper/1131121/en

    Vancouver: Copy

    MAGHSOUDI HOSSEIN, Yazadanpanah Enayatollah. Evaluation of the Anti-Inflammatory Properties of D-limonene Compared with Dexamethasone and Ibuprofen in Bovine Synoviocyte. JOURNALS OF BASIC RESEARCH IN MEDICAL SCIENCES[Internet]. 2023;10(1):1-14. Available from: https://sid.ir/paper/1131121/en

    IEEE: Copy

    HOSSEIN MAGHSOUDI, and Enayatollah Yazadanpanah, “Evaluation of the Anti-Inflammatory Properties of D-limonene Compared with Dexamethasone and Ibuprofen in Bovine Synoviocyte,” JOURNALS OF BASIC RESEARCH IN MEDICAL SCIENCES, vol. 10, no. 1, pp. 1–14, 2023, [Online]. Available: https://sid.ir/paper/1131121/en

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