The effect of Naringin on hippocampal cell damage and the antioxidant defense system of the fetal forebrain in an animal model of uteroplacental insufficiency

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Nemati Samireh; EDALATMANESH MOHAMMAD AMIN; FOROUZANFAR MOHSEN

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Journal Paper

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Journal: Medical Sciences Journal of Islamic Azad University,Tehran Medical Branch Year:2023 | Volume:33 | Issue:2 Page(s): 122-132

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Title

The effect of Naringin on hippocampal cell damage and the antioxidant defense system of the fetal forebrain in an animal model of uteroplacental insufficiency

Author(s)

Nemati Samireh | EDALATMANESH MOHAMMAD AMIN | FOROUZANFAR MOHSEN | Issue Writer Certificate

Keywords

Intrauterine growth restriction

Naringin

oxidative stress

hippocampus

rat

Abstract

Background: Uteroplacental insufficiency (UPI) by inducing oxidative stress in the fetal brain leads to disruption of its development. The present study evaluated the effects of Naringin on the antioxidant defense system in the fetal forebrain and prevention of the hippocampal damage following UPI. Materials and methods: 20 pregnant Wistar rats were randomly divided into 4 groups: control, UPI+Saline, UPI+Nar50 (UPI+Naringin with a dose of 50 mg/kg) and UPI+Nar100 (UPI+ Naringin with a dose of 100 mg/kg). In order to induce UPI, permanent occlusion of the anterior uterine vessels was performed on the embryonic day (ED) 18. Naringin and saline were gavagd from ED12-18. On the ED21, measuring the level of catalase (CAT), superoxide dismutase (SOD) and antioxidant capacity (TAC) by ELISA technique and malondialdehyde (MDA) by thiobarbituric acid method in the fetal forebrain and evaluating neuronal density in the CA1 and CA3 areas of the hippocampus were done. Results: A significant decrease in the brain activity of CAT, SOD, TAC and neuronal density in the CA1/CA3 areas of the hippocampus along with a significant increase in MDA was seen in the UPI+Saline group compared to the control group (p<0.05). While, a significant increase in CAT, SOD, TAC and CA1/CA3 neuronal density and a significant decrease in MDA was seen in the groups receiving Naringin compared to the UPI+Saline group (p<0.05). Conclusion: Administering Naringin before induction of UPI by strengthening the antioxidant system in the fetal forebrain caused the prevention of neurological complications caused by UPI in the fetal brain.

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APA: Copy

Nemati, Samireh, EDALATMANESH, MOHAMMAD AMIN, & FOROUZANFAR, MOHSEN. (2023). The effect of Naringin on hippocampal cell damage and the antioxidant defense system of the fetal forebrain in an animal model of uteroplacental insufficiency. MEDICAL SCIENCES JOURNAL OF ISLAMIC AZAD UNIVERSITY, 33(2 ), 122-132. SID. https://sid.ir/paper/1131616/en

Vancouver: Copy

Nemati Samireh, EDALATMANESH MOHAMMAD AMIN, FOROUZANFAR MOHSEN. The effect of Naringin on hippocampal cell damage and the antioxidant defense system of the fetal forebrain in an animal model of uteroplacental insufficiency. MEDICAL SCIENCES JOURNAL OF ISLAMIC AZAD UNIVERSITY[Internet]. 2023;33(2 ):122-132. Available from: https://sid.ir/paper/1131616/en

IEEE: Copy

Samireh Nemati, MOHAMMAD AMIN EDALATMANESH, and MOHSEN FOROUZANFAR, “The effect of Naringin on hippocampal cell damage and the antioxidant defense system of the fetal forebrain in an animal model of uteroplacental insufficiency,” MEDICAL SCIENCES JOURNAL OF ISLAMIC AZAD UNIVERSITY, vol. 33, no. 2 , pp. 122–132, 2023, [Online]. Available: https://sid.ir/paper/1131616/en

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