Effect of a High and Medium Intensity Interval Training Period with Liposomal Alpha-Lipoic Acid Supplementation on the Expression of Sema3A Protein in the Soleus Muscle of the Induced Diabetic Rats

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Fatemi Seyedeh Fatemeh; Hashemvarzi Seyed Abdollah; DADBAN SHAHAMAT MINOO; Farzaneh Hessari Amin

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Journal Paper

Paper Information

Journal: JOURNAL OF GORGAN UNIVERSITY OF MEDICAL SCIENCES Year:2023 | Volume:25 | Issue:2 (86) Page(s): 22-31

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Title

Effect of a High and Medium Intensity Interval Training Period with Liposomal Alpha-Lipoic Acid Supplementation on the Expression of Sema3A Protein in the Soleus Muscle of the Induced Diabetic Rats

Author(s)

Fatemi Seyedeh Fatemeh | Hashemvarzi Seyed Abdollah | DADBAN SHAHAMAT MINOO | Farzaneh Hessari Amin | Issue Writer Certificate

Keywords

Alpha-lipoic acid

Interval Training

Semaphorin

Diabetes Mellitus

Abstract

Background and Objective: Diabetes leads to impaired blood supply to the peripheral nerves. Sema3A (Semaphorin 3A) is a denervated protein that increases in response to hyperglycemia caused by diabetes. Exercise and Alpha-lipoic acid (ALA) supplements can protect against diabetes-induced denervation. This study was done to evaluate the effect of high and moderate-intensity Interval Training with Alpha-lipoic acid supplementation on the expression of Sema3A protein in the soleus muscle of Induced diabetic rats. Methods: In this experimental study, thirty-five male Wistar rats (weight range: 190-220 g, 6-8 weeks old) were randomly allocated into seven groups of five: healthy control, diabetic, diabetic supplement (S), diabetic high-intensity training (HIT), diabetic moderate-intensity training (MIT), diabetic high intensity+supplement (HIT+S), and diabetic moderate intensity training+supplement (MIT+S). Diabetes was induced by injection of streptozotocin (50 mg/kg/bw). The HIT and MIT protocols were performed five days a week for six weeks. ALA was administered orally at 20 mg/kg daily by gavage. Immunohistochemistry was used to evaluate the expression of Sema3A protein in the soleus muscle. Serum insulin was measured by the ELISA method. Results: Diabetes leads to increased level of glucose, Sema3A, and a significant decrease in insulin in the soleus muscle compared to healthy (P<0. 05). HIT and MIT in combination with ALA, significantly showed lower expression of Sema3A Protein than in the diabetic group (P<0. 05). Conclusion: Although HIT and MIT can reduce the expression of Sema3A protein in the soleus muscle of diabetic rats, combining Alpha-lipoic acid supplementation with exercise training is more effective in reducing the amount of denervation.

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APA: Copy

Fatemi, Seyedeh Fatemeh, Hashemvarzi, Seyed Abdollah, DADBAN SHAHAMAT, MINOO, & Farzaneh Hessari, Amin. (2023). Effect of a High and Medium Intensity Interval Training Period with Liposomal Alpha-Lipoic Acid Supplementation on the Expression of Sema3A Protein in the Soleus Muscle of the Induced Diabetic Rats. JOURNAL OF GORGAN UNIVERSITY OF MEDICAL SCIENCES, 25(2 (86) ), 22-31. SID. https://sid.ir/paper/1132427/en

Vancouver: Copy

Fatemi Seyedeh Fatemeh, Hashemvarzi Seyed Abdollah, DADBAN SHAHAMAT MINOO, Farzaneh Hessari Amin. Effect of a High and Medium Intensity Interval Training Period with Liposomal Alpha-Lipoic Acid Supplementation on the Expression of Sema3A Protein in the Soleus Muscle of the Induced Diabetic Rats. JOURNAL OF GORGAN UNIVERSITY OF MEDICAL SCIENCES[Internet]. 2023;25(2 (86) ):22-31. Available from: https://sid.ir/paper/1132427/en

IEEE: Copy

Seyedeh Fatemeh Fatemi, Seyed Abdollah Hashemvarzi, MINOO DADBAN SHAHAMAT, and Amin Farzaneh Hessari, “Effect of a High and Medium Intensity Interval Training Period with Liposomal Alpha-Lipoic Acid Supplementation on the Expression of Sema3A Protein in the Soleus Muscle of the Induced Diabetic Rats,” JOURNAL OF GORGAN UNIVERSITY OF MEDICAL SCIENCES, vol. 25, no. 2 (86) , pp. 22–31, 2023, [Online]. Available: https://sid.ir/paper/1132427/en

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