The effect of eight weeks of high-intensity interval training on changes in the levels of leptin, adiponectin and insulin levels in male Wistar rats

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Pirani Hossein; Salehi Omid Reza; Khoramipour Kayvan; Golestaneh Fereshteh

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Journal Paper

Paper Information

Journal: Journal of Birjand University of Medical Sciences Year:2023 | Volume:30 | Issue:3 Page(s): 268-279

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Information Journal Paper

Title

The effect of eight weeks of high-intensity interval training on changes in the levels of leptin, adiponectin and insulin levels in male Wistar rats

Author(s)

Pirani Hossein | Salehi Omid Reza | Khoramipour Kayvan | Golestaneh Fereshteh | Issue Writer Certificate

Keywords

AdiponectinQ4

Diabetes MellitusQ4

Glycemic IndexQ4

High-Intensity Interval TrainingQ4

LeptinQ4

Abstract

Background and Aims: Obesity leads to impaired secretion and expression of adipokines in humans and causes the onset of type 2 diabetes. Although the role of regular exercise in the prevention of metabolic diseases has been reported, the mechanism of high-intensity exercise is still not well understood. Therefore, the aim of the present study was to investigate the effects of 8 weeks of High-Intensity Interval Training on the changes in insulin, Leptin and Adiponectin levels in male Wistar rats with type 2 diabetes. Materials and Methods: In this experimental study 20 male Wistar rats aged 8-10 weeks were randomly divided into four groups: Control, type 2 diabetes, exercise, and diabetes-exercise. Type 2 diabetes was induced by a high-fat diet and a single dose of streptozotocin (STZ). The rats in the exercise and diabetes-exercise groups completed 8 weeks of HIIT training (running at an intensity of 85-95% of maximum speed, intervals of 4-10). Insulin, Adiponectin and Leptin levels were measured in serum. Homeostasis Model Assessment for Insulin Resistance (HOMA-IR), the Homeostasis Model Assessment for Insulin Resistance-beta (HOMA-β) and the Quantitative Assessment of Insulin Sensitivity Index (QUICKI) were calculated to assess insulin resistance and sensitivity. Results: Diabetes decreased the level of insulin, Adiponectin and Leptin in serum. HIIT reversed the impairments caused by diabetes. HOMA-IR, HOMA-β and QUICKI also improved in the diabetes-exercise groups. Conclusion: Overall, our results confirmed that diabetes has detrimental effects on serum Leptin, Adiponectin and insulin indices and that HIIT training can improve these disorders.

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