Association between Pre-miR-3131 rs57408770 and PrimiR-34b/c rs4938723 Gene Polymorphisms and the Risk of Non-Hodgkin Lymphoma

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BAHARI GHOLAMREZA; POORJANGI Mahsa; HASHEMI SEYED MEHDI; Bahari Masoomeh; TAHERI MOHSEN

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Journal: Koomesh Year:2023 | Volume:25 | Issue:2 (94) Page(s): 160-166

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Title

Association between Pre-miR-3131 rs57408770 and PrimiR-34b/c rs4938723 Gene Polymorphisms and the Risk of Non-Hodgkin Lymphoma

Author(s)

Keywords

Polymorphism

Pre

miR

3131 rs57408770

Pri

miR

34b / c rs4938723

Non

Hodgkin's Lymphoma

Abstract

Introduction: Lymphoma is the seventh most common malignancy worldwide, which is divided into types of neoplasms, of which three types, Hodgkin's Lymphoma (HL), Non-Hodgkin's Lymphoma (NHL), and Burkitt's lymphoma are the most common. miRNAs are regulators of gene exPression that are involved in physiological processes and are involved in cancer. In the Present study, the Polymorphisms of Pre-miR-3131 rs57408770 and PrimiR-34b/c rs4938723 genes in patients with Non-Hodgkin's Lymphoma were compared with healthy controls. Materials and Methods: In this case-control study, 359 specimens were studied, of which 173 were (NHL) patients and 186 were healthy controls. Patients were selected from the patients referred to the cancer clinic of Ali Ibn Abi Talib Hospital. The DNA genome was extracted from the peripheral blood sample by the salting out method. The variants of Pri-miR-34b/c rs4938723 and Pre-miR-3131 rs57408770 genotypes were analyzed by PCRRFLP method. Results: The results showed that Pri-miR-34b/c rs4938723 homozygous Polymorphism increased the risk of (NHL) in codominant and Recessive models. (OR= 2. 70, 95% CI =1. 13-4. 43, P=0. 025, OR=2. 91, CI 95% =1. 17-7. 42, P=0. 018 respectively). Pre-miR-3131 rs57408770 Polymorphism increased the risk of (NHL) in homozygous states in codominant and recessive models. (OR=2. 26, 95% CI=1. 21-4. 25, P=0. 006, respectively). Conclusion: The results showed a significant relationship between Pre-miR-3131 rs57408770 Polymorphism, Pri-miR-34b / c rs4938723, and (NHL) disease in the Iranian population.

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APA: Copy

BAHARI, GHOLAMREZA, POORJANGI, Mahsa, HASHEMI, SEYED MEHDI, Bahari, Masoomeh, & TAHERI, MOHSEN. (2023). Association between Pre-miR-3131 rs57408770 and PrimiR-34b/c rs4938723 Gene Polymorphisms and the Risk of Non-Hodgkin Lymphoma. KOOMESH, 25(2 (94) ), 160-166. SID. https://sid.ir/paper/1134572/en

Vancouver: Copy

BAHARI GHOLAMREZA, POORJANGI Mahsa, HASHEMI SEYED MEHDI, Bahari Masoomeh, TAHERI MOHSEN. Association between Pre-miR-3131 rs57408770 and PrimiR-34b/c rs4938723 Gene Polymorphisms and the Risk of Non-Hodgkin Lymphoma. KOOMESH[Internet]. 2023;25(2 (94) ):160-166. Available from: https://sid.ir/paper/1134572/en

IEEE: Copy

GHOLAMREZA BAHARI, Mahsa POORJANGI, SEYED MEHDI HASHEMI, Masoomeh Bahari, and MOHSEN TAHERI, “Association between Pre-miR-3131 rs57408770 and PrimiR-34b/c rs4938723 Gene Polymorphisms and the Risk of Non-Hodgkin Lymphoma,” KOOMESH, vol. 25, no. 2 (94) , pp. 160–166, 2023, [Online]. Available: https://sid.ir/paper/1134572/en

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