The effect of Thymoquinone on Peripheral Blood Mononuclear Cells (PBMCs) viability of patients with BChronic Lymphocytic Leukemia

Q: How can I download an article?

To download an article from SID, first log in to the site, search for the article title, and click on the 'Download Article' option.

Q: How can I download an ISI article?

To download an ISI article on SID, enter the keyword or article title in the search bar, view the relevant results, click on the desired article, and select the 'Download Article' option.

Q: How can I access the SID database?

To access the SID database, visit SID.ir, create an account, and log in to access scientific resources.

Q: Is downloading articles from SID free?

Some articles on SID are available for free, while others require payment. Details are specified on the article's page.

Mohammadlou Maryam; Hemati Maral; ABDOLLAHI MARYAM; Pashaei Mehrnoosh; GHAHREMANFARD FARAHNAZ; KOKHAEI PARVIZ

مرکز اطلاعات علمی Scientific Information Database (SID) - Trusted Source for Research and Academic Resources

Journal Paper

Paper Information

Journal: Koomesh Year:2023 | Volume:25 | Issue:2 (94) Page(s): 145-151

Download Full-Text

Persian Verion

View:

Download:

Cites:

Information Journal Paper

Title

The effect of Thymoquinone on Peripheral Blood Mononuclear Cells (PBMCs) viability of patients with BChronic Lymphocytic Leukemia

Author(s)

Keywords

Chronic Lymphocytic Leukemia

Thymoquinone

Apoptosis

Mononuclear Leukocytes

Abstract

Introduction: Chronic Lymphocytic Leukemia (CLL) as a lymphoproliferative disorder that is characterized by the expansion of monoclonal, mature CD5+CD23+ B cells in the peripheral blood, secondary lymphoid tissues, and bone marrow is facing with advent of new therapies targeting crucial biological pathways. Thymoquinone (TQ) is the major bioactive constituent in black seed oil (Nigella sativa) and has been found to exert anti-tumor impacts mainly through the induction of Apoptosis. This study aimed to evaluate the in vitro anti-leukemia effects of TQ on peripheral blood mononuclear cells (PBMCs) of CLL patients. Materials and Methods: Peripheral blood mononuclear cells (PBMCs) of 6 patients and 6 healthy donors were treated with 15 μ, g/ml of TQ for 24 h. The cytotoxic effect of TQ was assessed using the MTT assay. Flow cytometry was used to analyze the Apoptosis of PBMCs. Results: Treatment with TQ increased the cytotoxicity of PBMCs of CLL patients more significantly than in Untreated cells (P=0. 021). Flow cytometry results indicated that TQ exhibited a significant apoptotic impact on PBMCs of CLL patients compared to the healthy subjects (P=0. 001). TQ also induced marked Apoptosis in CLL cells compared to the Untreated cells (P=0. 006). Conclusion: Our findings reveal that TQ possesses promising therapeutic potential as an anti-tumor agent for treating CLL mainly through the induction of cell Apoptosis and cytotoxicity.

Cites

No record.

References

No record.

Cite

APA: Copy

Mohammadlou, Maryam, Hemati, Maral, ABDOLLAHI, MARYAM, Pashaei, Mehrnoosh, GHAHREMANFARD, FARAHNAZ, & KOKHAEI, PARVIZ. (2023). The effect of Thymoquinone on Peripheral Blood Mononuclear Cells (PBMCs) viability of patients with BChronic Lymphocytic Leukemia. KOOMESH, 25(2 (94) ), 145-151. SID. https://sid.ir/paper/1134589/en

Vancouver: Copy

Mohammadlou Maryam, Hemati Maral, ABDOLLAHI MARYAM, Pashaei Mehrnoosh, GHAHREMANFARD FARAHNAZ, KOKHAEI PARVIZ. The effect of Thymoquinone on Peripheral Blood Mononuclear Cells (PBMCs) viability of patients with BChronic Lymphocytic Leukemia. KOOMESH[Internet]. 2023;25(2 (94) ):145-151. Available from: https://sid.ir/paper/1134589/en

IEEE: Copy

Maryam Mohammadlou, Maral Hemati, MARYAM ABDOLLAHI, Mehrnoosh Pashaei, FARAHNAZ GHAHREMANFARD, and PARVIZ KOKHAEI, “The effect of Thymoquinone on Peripheral Blood Mononuclear Cells (PBMCs) viability of patients with BChronic Lymphocytic Leukemia,” KOOMESH, vol. 25, no. 2 (94) , pp. 145–151, 2023, [Online]. Available: https://sid.ir/paper/1134589/en

Related Journal Papers

No record.

Related Seminar Papers

No record.

Related Plans

No record.

Recommended Workshops