مرکز اطلاعات علمی Scientific Information Database (SID) - Trusted Source for Research and Academic Resources

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Information Journal Paper

Title

Production of radioimmunoPET grade zirconium-89

Pages

  20-28

Abstract

 Introduction: Particular characteristics of 89 Zr to produce various labeled compounds are crucial for developing radioimmunopharmaceuticals for clinical trials. This study aimed to produce 89 Zr for radiolabeling purposes as radioimmunoPET grade precursor. Methods: The computational calculations for 89 Zr Production via 89 89 Y(p, n) Zr reaction were performed using TALYS-1. 8 and ALICE-91. 89 Zr was produced by the proton bombardment of the yttrium pellet using a 30 MeV Cyclotron. ZR resin was used for the separation of 89 Zr from the target. The radionuclidic purity was assessed by a high purity germanium detector. The inductively coupled plasma spectrometry and instant thin layer chromatography methods were considered for chemical and radiochemical purity assessments, respectively. The biodistribution of [89Zr]Zr-oxalate was studied in Wistar rats by both sacrification and imaging. [89Zr]Zr-DFO-trastuzumab was produced as a proof of concept for a radioimmunoPET labeling. Results: Considering the cross-section of 89 89 Y(p, n) Zr reaction, 14 MeV proton energy was selected for 89 Zr Production, while the yttrium pellet target was irradiated at least for 125 µ, Ah, . 89 Zr was finally prepared with a yield of 25. 9±, 1. 48 MBq/µ, Ah, a specific activity of 344. 1 MBq/µ, g, the radionuclidic and radiochemical purity higher than 99. 99% and 99%, respectively. Total amount of the metal ions in the final solution was less than 0. 1 ppm. Biodistribution of [ 89 Zr]Zr-oxalate demonstrated high accumulation in the bone, lungs, and heart. 89 [ Zr]Zr-DFO-trastuzumab was produced with a radiochemical purity higher than 99% and specific activity of 74 GBq/g in about 2 hours. Conclusion: [89Zr]Zr-oxalate was produced with suitable activity and high purity for the preparation of the radioimmunopharmaceuticals.

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    Cite

    APA: Copy

    Mohammadpour Ghazi, Fatemeh, YOUSEFNIA, HASSAN, ZOLGHADRI, SAMANEH, Yarmohammadi, Mohammad, Alirezapour, Behrouz, & ASLANI, GHOLAMREZA. (2023). Production of radioimmunoPET grade zirconium-89. IRANIAN JOURNAL OF NUCLEAR MEDICINE, 31(1 (SERIAL NUMBER 60)), 20-28. SID. https://sid.ir/paper/1134713/en

    Vancouver: Copy

    Mohammadpour Ghazi Fatemeh, YOUSEFNIA HASSAN, ZOLGHADRI SAMANEH, Yarmohammadi Mohammad, Alirezapour Behrouz, ASLANI GHOLAMREZA. Production of radioimmunoPET grade zirconium-89. IRANIAN JOURNAL OF NUCLEAR MEDICINE[Internet]. 2023;31(1 (SERIAL NUMBER 60)):20-28. Available from: https://sid.ir/paper/1134713/en

    IEEE: Copy

    Fatemeh Mohammadpour Ghazi, HASSAN YOUSEFNIA, SAMANEH ZOLGHADRI, Mohammad Yarmohammadi, Behrouz Alirezapour, and GHOLAMREZA ASLANI, “Production of radioimmunoPET grade zirconium-89,” IRANIAN JOURNAL OF NUCLEAR MEDICINE, vol. 31, no. 1 (SERIAL NUMBER 60), pp. 20–28, 2023, [Online]. Available: https://sid.ir/paper/1134713/en

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