EVALUATION OF REFLECTION OPTICAL IMAGING CHARACTERISTICS USING FLUORESCENCE WITH NEAR INFRARED WAVELENGTH AT DIFFERENT DEPTHS OF TISSUE EQUIVALENT PHANTOM

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SHOUGHI H.; HEJAZI MARJANEH; OGHABIAN M.A.; MASOUDI REZA; MOHAMMAD REZA H.; SHIRKAVAND A.

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Journal: Lasers in Medicine Year:2009 | Volume:5 | Issue:3-4 (29-30) Page(s): 29-35

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Title

EVALUATION OF REFLECTION OPTICAL IMAGING CHARACTERISTICS USING FLUORESCENCE WITH NEAR INFRARED WAVELENGTH AT DIFFERENT DEPTHS OF TISSUE EQUIVALENT PHANTOM

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Keywords

FLUORESCENCE REFLECTANCE IMAGING (FRI)Q4

POINT SPREAD FUNCTION (PSF)Q3

RESOLVING POWERQ4

DEPTHQ4

PHANTOMQ4

Abstract

Introduction: Fluorescence reflectance imaging (FRI) is applied for detecting the presence of fluorescence sources within biological tissue. The main limitation of conventional FRI systems is a low imagine DEPTH because biological tissues absorb light at visible wavelength. More recent development in FRI imaging in using near infra-red wavelength enabling the reconstruction of deep seated fluorescence source. The goal of this study was to determine FRI image characterization in the near infra-red wavelength region.materials and methods: The image characterization was based on deriving DEPTH dependent point spread function of a RFI system. The FRI system was implemented using Diode laser 5mW at 630nm, telescopic lenses mirrors al long pass filter and sensitive CCD camera. A-2-mmidiameter hollow sphere containing quantum dot (QD) or indocyanine green (ICG) was placed at the bottom of a PHANTOM with tissue-like optical parameters (with ms=8.1cm-1, ma=0.11 cm-1). FRI images were recorded for varying thickness d of the PHANTOM on top of the florescent spheres. The acquired image were deconvolved with original image for extracting the DEPTH dependent PSF, with the width defined as full width at half maximum (FWHM) on the basis of Gaussian fitting Homogeneous medium. Additionally variation of PSF FWHM was also evaluated by changing the florescent concentration, source radius and magnification. Finally RESOLVING POWER of FRI system was measured according to reyleigh criterion.Results: The evaluation showed that at the DEPTH of 2- 5mm, the DEPTH of ICG and quantum dot was overestimated 9% and 11% respectively. By increasing 1CG concentration, errors in DEPTH reconstruction were decreased. But the error was increased by increasing the quantum dot concentration. The FRI system cans clearly resolved point sources with 4mm apart seated maximum at 3 mm DEPTH.Conclusion: The results suggested that the developed FRI system can be used in small animal imaging for imaging superficial tumors.

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APA: Copy

SHOUGHI, H., HEJAZI, MARJANEH, OGHABIAN, M.A., MASOUDI, REZA, MOHAMMAD REZA, H., & SHIRKAVAND, A.. (2009). EVALUATION OF REFLECTION OPTICAL IMAGING CHARACTERISTICS USING FLUORESCENCE WITH NEAR INFRARED WAVELENGTH AT DIFFERENT DEPTHS OF TISSUE EQUIVALENT PHANTOM. LASER IN MEDICINE, 5(3-4 (29-30)), 29-35. SID. https://sid.ir/paper/113527/en

Vancouver: Copy

SHOUGHI H., HEJAZI MARJANEH, OGHABIAN M.A., MASOUDI REZA, MOHAMMAD REZA H., SHIRKAVAND A.. EVALUATION OF REFLECTION OPTICAL IMAGING CHARACTERISTICS USING FLUORESCENCE WITH NEAR INFRARED WAVELENGTH AT DIFFERENT DEPTHS OF TISSUE EQUIVALENT PHANTOM. LASER IN MEDICINE[Internet]. 2009;5(3-4 (29-30)):29-35. Available from: https://sid.ir/paper/113527/en

IEEE: Copy

H. SHOUGHI, MARJANEH HEJAZI, M.A. OGHABIAN, REZA MASOUDI, H. MOHAMMAD REZA, and A. SHIRKAVAND, “EVALUATION OF REFLECTION OPTICAL IMAGING CHARACTERISTICS USING FLUORESCENCE WITH NEAR INFRARED WAVELENGTH AT DIFFERENT DEPTHS OF TISSUE EQUIVALENT PHANTOM,” LASER IN MEDICINE, vol. 5, no. 3-4 (29-30), pp. 29–35, 2009, [Online]. Available: https://sid.ir/paper/113527/en

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