MICROINJECTION OF OREXIN-A INTO THE LOCUS COERULEUS AREA INDUCES MORPHINE WITHDRAWAL BEHAVIORS IN MORPHINE INDEPENDENT RATS

Q: How can I download an article?

To download an article from SID, first log in to the site, search for the article title, and click on the 'Download Article' option.

Q: How can I download an ISI article?

To download an ISI article on SID, enter the keyword or article title in the search bar, view the relevant results, click on the desired article, and select the 'Download Article' option.

Q: How can I access the SID database?

To access the SID database, visit SID.ir, create an account, and log in to access scientific resources.

Q: Is downloading articles from SID free?

Some articles on SID are available for free, while others require payment. Details are specified on the article's page.

AZIZI H.; HADIAN A.; SEMNANIAN S.

مرکز اطلاعات علمی Scientific Information Database (SID) - Trusted Source for Research and Academic Resources

Journal Paper

Paper Information

Journal: RESEARCH ON ADDICTION Year:2012 | Volume:5 | Issue:20 Page(s): 105-117

Download Full-Text

Persian Verion

View:

1,016

Download:

Cites:

Information Journal Paper

Title

MICROINJECTION OF OREXIN-A INTO THE LOCUS COERULEUS AREA INDUCES MORPHINE WITHDRAWAL BEHAVIORS IN MORPHINE INDEPENDENT RATS

Author(s)

AZIZI H. | HADIAN A. | SEMNANIAN S. | Issue Writer Certificate

Keywords

OREXIN-AQ2

MORPHINE WITHDRAWAL SYNDROMEQ2

LOCUS COERULEUSQ2

Abstract

Introduction: Orexin neuropeptide has a role in opioid withdrawal behaviors. Orexin-expressing neurons that are present in the hypothalamic nuclei send dense projections to the LOCUS COERULEUS (LC). Withdrawal syndrome is temporally associated with hyperactivity of LC neurons. LC neurons do not show withdrawal-induced hyperactivity in brain slices from morphine-dependent rats. Thus, it has been suggested that the increase in LC neuronal activity seen in vivo is mediated by extrinsic factors. Therefore, this study was carried out to find whether LC microinjection of OREXIN-A can induce withdrawal behaviors.Method: Adult male Wistar rats were used in this study. Intra-LC microinjection of OREXIN-A or OREXIN-A vehicle was performed one week after LC cannulation. Thereafter, somatic signs of withdrawal were evaluated during a period of 25 min.Findings: OREXIN-A induced several signs of morphine withdrawal.Conclusion: It may be concluded that orexin at LC acts as an extrinsic factor in the expression of MORPHINE WITHDRAWAL SYNDROME.

Cites

No record.

References

No record.

Cite

APA: Copy

AZIZI, H., HADIAN, A., & SEMNANIAN, S.. (2012). MICROINJECTION OF OREXIN-A INTO THE LOCUS COERULEUS AREA INDUCES MORPHINE WITHDRAWAL BEHAVIORS IN MORPHINE INDEPENDENT RATS. RESEARCH ON ADDICTION, 5(20), 105-117. SID. https://sid.ir/paper/113743/en

Vancouver: Copy

AZIZI H., HADIAN A., SEMNANIAN S.. MICROINJECTION OF OREXIN-A INTO THE LOCUS COERULEUS AREA INDUCES MORPHINE WITHDRAWAL BEHAVIORS IN MORPHINE INDEPENDENT RATS. RESEARCH ON ADDICTION[Internet]. 2012;5(20):105-117. Available from: https://sid.ir/paper/113743/en

IEEE: Copy

H. AZIZI, A. HADIAN, and S. SEMNANIAN, “MICROINJECTION OF OREXIN-A INTO THE LOCUS COERULEUS AREA INDUCES MORPHINE WITHDRAWAL BEHAVIORS IN MORPHINE INDEPENDENT RATS,” RESEARCH ON ADDICTION, vol. 5, no. 20, pp. 105–117, 2012, [Online]. Available: https://sid.ir/paper/113743/en

Related Journal Papers