مرکز اطلاعات علمی Scientific Information Database (SID) - Trusted Source for Research and Academic Resources

Persian Verion
مرکز اطلاعات علمی Scientific Information Database (SID) - Trusted Source for Research and Academic Resources

video

مرکز اطلاعات علمی Scientific Information Database (SID) - Trusted Source for Research and Academic Resources

sound

مرکز اطلاعات علمی Scientific Information Database (SID) - Trusted Source for Research and Academic Resources

Persian Version

مرکز اطلاعات علمی Scientific Information Database (SID) - Trusted Source for Research and Academic Resources

View:

625
مرکز اطلاعات علمی Scientific Information Database (SID) - Trusted Source for Research and Academic Resources

Download:

0
مرکز اطلاعات علمی Scientific Information Database (SID) - Trusted Source for Research and Academic Resources

Cites:

Information Journal Paper

Title

Morphine dependence increases gene expression of orexin type one receptors in locus coeruleus nucleus

Pages

  246-252

Abstract

 Background and aims: Repetitive administRation of opioid agonists induced dependency to these substances and thus limits their clinical usage. The locus coeruleus (LC) is a key brain structure implicated in dependency tolerance and the expression of somatic signs of morphine withdrawal syndrome. Orexin is a neuropeptide that involve in morphine tolerance and dependence, as well. OX1R has been detected in LC nucleus. In this study we examined the expression of OX1R during dependency and also in the withdrawal syndrome in neurons of LC nucleus in Rats. Methods: To incite dependency, morphine sulfate (10 mg/kg) was injected intraperitoneally twice a day for 10 days in male Wistar Rats. For induction of withdrawal syndrome, naloxone was injected (2 mg/kg) subcutaneously in day 10, two hours after the last injection of morphine. In order to measure the expression of OX1R, RT-PCR was used. Results: This study shows that morphine dependency leads to increase expression of OX1R in neurons of LC nucleus. We also observed that morphine withdrawal syndrome with naloxone induced decreasing of OX1R expression in this region. In another word, amounts of this receptors back to normal level before dependency. Conclusion: Due to results obtained from this study, we observed an increase in the expression of OX1R in neurons of LC nucleus and also return in the level of this receptors to baseline after exposure to naloxone and withdrawal syndrome. Hence we could suggest that OX1Rs in LC nucleus are involved in dependency and withdrawal syndrome.

Cites

  • No record.

    • References

  • No record.

    • Cite

    APA: Copy

    Aghajani, Niloofar, AZIZI, HOSSEIN, JAVAN, MOHAMMAD, & SEMNANIAN, SAEED. (2020). Morphine dependence increases gene expression of orexin type one receptors in locus coeruleus nucleus. IRANIAN JOURNAL OF PHYSIOLOGY AND PHARMACOLOGY, 3(4 (12) ), 246-252. SID. https://sid.ir/paper/391364/en

    Vancouver: Copy

    Aghajani Niloofar, AZIZI HOSSEIN, JAVAN MOHAMMAD, SEMNANIAN SAEED. Morphine dependence increases gene expression of orexin type one receptors in locus coeruleus nucleus. IRANIAN JOURNAL OF PHYSIOLOGY AND PHARMACOLOGY[Internet]. 2020;3(4 (12) ):246-252. Available from: https://sid.ir/paper/391364/en

    IEEE: Copy

    Niloofar Aghajani, HOSSEIN AZIZI, MOHAMMAD JAVAN, and SAEED SEMNANIAN, “Morphine dependence increases gene expression of orexin type one receptors in locus coeruleus nucleus,” IRANIAN JOURNAL OF PHYSIOLOGY AND PHARMACOLOGY, vol. 3, no. 4 (12) , pp. 246–252, 2020, [Online]. Available: https://sid.ir/paper/391364/en

    Related Journal Papers

  • No record.

    • Related Seminar Papers

  • No record.

    • Related Plans

  • No record.

    • Recommended Workshops






    Move to top
    telegram sharing button
    whatsapp sharing button
    linkedin sharing button
    twitter sharing button
    email sharing button
    email sharing button
    email sharing button
    sharethis sharing button