Expression of MicroRNA-155-5p in Chronic Kidney Disease as a Potential Marker of Cardiovascular Complications

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Mohamed Hend Sayed; M. Alhabibi Alshaymaa; Elmaged Donia Ashraf Abd; Elsawy Ghadir Mohamed; Ibrahim Nehad Refaat; Mohamed Mona A.

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ISSN: 2588-4824

Journal Paper

Paper Information

Journal: Journal of Medicinal and Chemical Sciences Year:2023 | Volume:6 | Issue:8 Page(s): 1737-1745

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Title

Expression of MicroRNA-155-5p in Chronic Kidney Disease as a Potential Marker of Cardiovascular Complications

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Keywords

Chronic kidney disease MicroRNAQ4

155Q4

5p Cardiovascular complications Glomerular filtration rate Polymerase chain reactionQ4

Abstract

Background: Chronic kidney disease (CKD) is a silent, serious condition requiring reliable non-invasive markers for diagnosing and predicting complications especially cardiovascular (CV)complications.Objectives: This study aims to detect microRNA-155-5p (miR-155-5p) as a potential marker of CKD and a predictor of CV complications.Subjects and methods: 120 participants were included in this study, and they were categorized as; Group I (n=60, healthy age- and sex-matched control group) and Group II (n = 60, CKD patients). Group II was subdivided into: Group IIA (n = 30 CKD patients without CV complications) and Group IIB (n = 30; CKD patients complicated with CV diseases). Using reverse transcription polymerase chain reaction (RT-PCR), miR-155-5p was detected.Results: miR-155-5p was increased in Group IIA and IIB compared with the control group, while miR-155-5p was increased in Group IIB compared with Group IIA.Conclusion: miR-155-5p can be used as a sensitive and specific marker for detecting CKD and discriminating between CKD with and without CV complications.

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